Antonella Capozzi

Pubblicazioni

Titolo Pubblicato in Anno
Autophagy promotes enrichment of raft components within extracellular vesicles secreted by human 2FTGH cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome: Molecular Mechanisms and Signaling through Lipid Rafts JOURNAL OF CLINICAL MEDICINE 2023
Antiphospholipid antibodies in patients with stroke during COVID-19: A role in the signaling pathway leading to platelet activation FRONTIERS IN IMMUNOLOGY 2023
Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells CELLS 2023
Oxidative stress as a regulatory checkpoint in the production of Antiphospholipid Autoantibodies: the protective role of NRF2 Pathway BIOMOLECULES 2023
The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells BIOMEDICINES 2023
Role of lipid rafts on LRP8 signaling triggered by anti-β2-GPI antibodies in endothelial cells BIOMEDICINES 2023
Gender-affirming hormone therapy and autoimmunity: new insights from a 3-year follow-up study CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2023
Carbamylation of β2-GPI generates new autoantigens for Antiphospholipid Syndrome. a new tool for diagnosis of "seronegative" patients RHEUMATOLOGY 2022
Signal transduction pathway involved in platelet activation in immune thrombotic thrombocytopenia after COVID-19 vaccination HAEMATOLOGICA 2022
Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti-β2-GPI antibodies: Reply to comment from Mackman et al JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2022
Anti-β2-GPI antibodies induce endothelial cell expression of tissue factor by LRP6 signal transduction pathway involving lipid rafts CELLS 2022
Relationship Between Gender Differences and Clinical Outcome in Patients With the Antiphospholipid Syndrome FRONTIERS IN IMMUNOLOGY 2022
Citrullinated and carbamylated proteins in extracellular microvesicles from plasma of patients with rheumatoid arthritis RHEUMATOLOGY 2022
The role of cardiolipin as a scaffold mitochondrial phospholipid in autophagosome formation: In vitro evidence BIOMOLECULES 2021
Effect of Heparanase inhibitor on Tissue Factor overexpression in platelets and endothelial cells induced by anti-β2-GPI antibodies JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2021
Anti-vimentin/cardiolipin IgA in the antiphospholipid syndrome: a new tool for “seronegative” diagnosis CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2021
Role of erlins in the control of cell fate through lipid rafts CELLS 2021
Overexpression of neuroglobin promotes energy metabolism and autophagy induction in human neuroblastoma SH-SY5Y cells CELLS 2021

ERC

  • LS1
  • LS1_1
  • LS1_2
  • LS1_9

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

NUOVE SPECIFICITÀ ANTIGENICHE E NUOVE TECNOLOGIE NELLA DIAGNOSI DELLA SINDROME DA ANTICORPI ANTIFOSFOLIPIDI
L’identificazione di nuovi “targets” antigenici (es. cardiolipina/vimentina) e l’utilizzo di nuove metodologie, quali il TLC immunostaining e la chemiluminescenza, hanno permesso di perfezionare i test “anti-fosfolipidi”, consentendo sia una diagnosi differenziale fra pazienti con malattie autoimmuni e malattie infettive, sia l’identificazione di quei soggetti che risultano negativi ai test standard di laboratorio (pazienti sieronegativi). Nell’ambito degli studi volti a chiarire quali meccanismi siano alla base della comparsa degli anticorpi "anti-fosfolipidi” nelle malattie autoimmuni, molto importante è risultato il ruolo dell’apoptosi cellulare. Gli anticorpi anti-2-GPI (principale marker sierologico della Sindrome) possono riconoscere forme ossidate o glicate della proteina, inducendo la maturazione delle cellule dendritiche e promuovendo risposte di tipo Th1. Gli anticorpi possono innescare una via di trasduzione del segnale nelle cellule monocitarie, che porta al coinvolgimento dei recettori tipo TOLL, all’attivazione di fattori NF-kB, con conseguente produzione di citochine proinfiammatorie e fattori procoagulanti. L’insieme di questi studi ha permesso di comprendere le specificità antigeniche e le vie di trasduzione del segnale innescate dagli “anticorpi anti-fosfolipidi” nelle malattie autoimmunitarie, chiarendone il meccanismo patogenetico.

Keywords

autoimmune desease
antiphospholipid antibody syndrome
new technologies
diagnosis

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