Maria Rosaria Ricciardi

Pubblicazioni

Titolo Pubblicato in Anno
High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma LEUKEMIA & LYMPHOMA 2017
Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia ADVANCES IN BIOLOGICAL REGULATION 2017
Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells SCIENTIFIC REPORTS 2017
Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin SCIENTIFIC REPORTS 2017
Tramesan, a novel polysaccharide from trametes versicolor. structural characterization and biological effects PLOS ONE 2017
Preclinical antileukemia activity of tramesan. A newly identified bioactive fungal metabolite OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay JOURNAL OF HEMATOLOGY & ONCOLOGY 2016
Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia SCIENTIFIC REPORTS 2016
PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression ONCOTARGET 2015
The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma ONCOTARGET 2015
Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia ONCOTARGET 2015
Targeting the leukemia cell metabolism by the CPT1a inhibition. functional pre-clinical effects in leukemias BLOOD 2015
The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling EXPERIMENTAL HEMATOLOGY 2015
The pan-class I PI3 kinase inhibitor, NVP-BKM120, demonstrates anti-leukemic activity in acute myeloid leukemia HAEMATOLOGICA 2015
Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment. CANCER RESEARCH 2015
Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212. GENES, CHROMOSOMES & CANCER 2015
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO JOURNAL 2015
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells JOURNAL OF IMMUNOLOGY 2015
The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia SCIENTIFIC REPORTS 2015

ERC

  • LS1_9
  • LS2_15
  • LS3_1
  • LS3_5
  • LS4_11

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Attività di ricerca clinica traslazionale in patologie ematologiche con lo scopo di stabilire correlazioni prognostiche tra parametri biologici e clinico-diagnostici.

Tra i temi principali della mia attività di ricerca vi è lo studio 1) dei pathway molecolari proliferativi e anti-apoptotici, 2) del profilo di espressione proteica/fosfoproteica e 3) del profilo metabolico di cellule primarie di pazienti leucemici allo scopo di identificare profili peculiari di specifiche alterazioni genomiche e/o proteomiche e di selezionare bersagli molecolari di innovative terapie mirate.

Keywords

Acute leukemia
molecular targeted therapies
metabolic profile
phosphoproteomics
drug resistance

Progetti di Ricerca

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