Speranza Donatella Rubattu | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation	CARDIOVASCULAR REVASCULARIZATION MEDICINE	2016
A next-generation sequencing approach to identify gene mutations in early-and late-onset hypertrophic cardiomyopathy patients of an Italian cohort	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2016
Mitochondrial dysfunction contributes to hypertensive target organ damage: lessons from an animal model of human disease	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY	2016
Natriuretic peptides and integrated risk assessment for cardiovascular disease. an individual-participant-data meta-analysis	THE LANCET DIABETES & ENDOCRINOLOGY	2016
Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells	MECHANISMS OF AGEING AND DEVELOPMENT	2016
An easy and reproducible parameter for the assessment of the pressure gradient in patients with aortic stenosis disease: a magnetic resonance study	JOURNAL OF CARDIOLOGY	2015
RyR2 common gene variant G1886S and the risk of ventricular arrhythmias in ICD patients with heart failure.	JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY	2015
Hypovitaminosis D and organ damage In patients with arterial hypertension: a multicenter double blind randomised controlled trial of cholecalciferol supplementation (HYPODD). Study design, clinical procedures and treatment protocol	HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION	2015
Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis	JOURNAL OF HYPERTENSION	2015
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains	ONCOTARGET	2015
Angiotensin II receptor blocker neprilysin inhibitor (ARNI). new avenues in cardiovascular therapy	HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION	2015
Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art	BIOMED RESEARCH INTERNATIONAL	2015
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro	CELL DEATH & DISEASE	2015

ERC

LS4_10

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.

Keywords

cardiovascular diseases

molecular mechanisms

animal models

mitochondria

natriuretic peptides

oxidative stress

genetics

autophagy

mitophagy

Progetti di Ricerca

Gruppi di ricerca

Disregolazione neurormonale nelle malattie cardiovascolari

Disfunzione mitocondriale e stress ossidativo nelle malattie cardiovascolari