Speranza Donatella Rubattu


Titolo Pubblicato in Anno
Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells EUROPEAN JOURNAL OF CELL BIOLOGY 2024
The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension FRONTIERS IN CARDIOVASCULAR MEDICINE 2024
Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
Obesity: the perfect storm for heart failure ESC HEART FAILURE 2024
Role of autophagy in ischemic stroke: insights from animal models and preliminary evidence in the human disease FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2024
The prognostic role of the echocardiographic tricuspid annular plane systolic excursion/systolic pulmonary arterial pressure (TAPSE/sPAP) ratio and its relationship with NT-proANP plasma level in systemic sclerosis FRONTIERS IN CARDIOVASCULAR MEDICINE 2023
A Novel Nonsense Pathogenic TTN Variant Identified in a Patient with Severe Dilated Cardiomyopathy CURRENT ISSUES IN MOLECULAR BIOLOGY 2023
Natriuretic Peptides: It Is Time for Guided Therapeutic Strategies Based on Their Molecular Mechanisms INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
NPPA/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart AUTOPHAGY 2023
1,5-disubstituted-1,2,3-triazoles counteract mitochondrial dysfunction acting on F1FO-ATPase in models of cardiovascular diseases PHARMACOLOGICAL RESEARCH 2023
Beneficial Effects of Citrus Bergamia Polyphenolic Fraction on Saline Load-Induced Injury in Primary Cerebral Endothelial Cells from the Stroke-Prone Spontaneously Hypertensive Rat Model NUTRIENTS 2023
Elabela Peptide: A New Player in Hypertension and Vascular Damage HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION 2023
Long QTc in hypertrophic cardiomyopathy: A consequence of structural myocardial damage or a distinct genetic disease? FRONTIERS IN CARDIOVASCULAR MEDICINE 2023
Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure CELLULAR AND MOLECULAR LIFE SCIENCES 2023
Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats CIRCULATION RESEARCH 2023
The role of genetic testing in suspected fulminant myocarditis: A case report MOLECULAR GENETICS AND METABOLISM REPORTS 2023
Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension MOLECULAR MEDICINE 2023
Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 2023
MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation CELLULAR AND MOLECULAR LIFE SCIENCES 2023
Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2023


  • LS4_10


  • Life-science technologies & biotechnologies

Interessi di ricerca

Renin-angiotensin-aldosterone system: systemic and tissue systems and their role in arterial hypertension.

Characterization of an animal model of arterial hypertension and target organ damage (the stroke-prone spontaneously hypertensive rat).

Molecular-genetic bases of target organ damage in hypertension (stroke, cardiac hypertrophy, renal damage) in an animal model and in humans.

Characterization of atrial natriuretic factor as a risk factor for cardiovascular diseases in the animal model and in humans.

Analysis of mitochondrial dysfunction as a molecular mechanism of hypertensive organ damage in an animal model and in humans.

Role of autophagy and mitophagy in cardiovascular diseases.



cardiovascular diseases
molecular mechanisms
animal models
natriuretic peptides
oxidative stress

Gruppi di ricerca

Laboratori di ricerca

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