Eugenio Barone | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model	NEUROBIOLOGY OF DISEASE	2024
Biliverdin reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β	REDOX BIOLOGY	2024
Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease	ANTIOXIDANTS	2024
Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome	AGING	2024
Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimer’s disease-like neuropathology in a mouse model for Down syndrome	ANTIOXIDANTS	2023
A Bioengineering Strategy to Control ADAM10 Activity in Living Cells	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Engineering memory with an extrinsically disordered kinase	SCIENCE ADVANCES	2023
Brain insulin resistance: An early risk factor for Alzheimer's disease development in down syndrome	NEURAL REGENERATION RESEARCH	2022
Aberrant protein networks in Alzheimer disease	NATURE REVIEWS. NEUROLOGY	2022
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome	FREE RADICAL BIOLOGY & MEDICINE	2022
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling	SCIENCE SIGNALING	2022
Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Insulin Signaling Regulates Mitochondrial Bioenergetics in the Brain: Insight for the Development of Neurodegenerative Diseases	FREE RADICAL BIOLOGY & MEDICINE	2022
Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome	FREE RADICAL BIOLOGY & MEDICINE	2021
High-fat diet leads to reduced protein o-glcnacylation and mitochondrial defects promoting the development of alzheimer’s disease signatures	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles	ALZHEIMER'S & DEMENTIA	2021
Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control	LIFE SCIENCES	2021
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease	FREE RADICAL BIOLOGY & MEDICINE	2021
mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder	FREE RADICAL BIOLOGY & MEDICINE	2021

Progetti di Ricerca

ABERRANT INSULIN SIGNALING CONTRIBUTES TO DEVELOPMENT OF ALZHEIMER DISEASE: SEARCH FOR NOVEL THERAPEUTIC STRATEGIES
Biliverdin reductase-A impairment mediates the development of insulin resistance in obesity and T2DM: a novel mechanism of action.
Unravelling a novel mechanism favoring brain insulin resistance development and its impact on Alzheimer disease neuropathology