Ricerc@Sapienza

My field of research concerns the characterization of the molecular mechanisms that underlie cell function during differentiation and development, in order to understand how these mechanisms are altered in pathological conditions and how they can be used in therapy. In particular, my primary interest is the RNA molecule.

We use induced Pluripotent Stem Cells (iPSCs) for the study of neurodegenerative and neurodevelopmental diseases. iPSCs can be derived from patients carrying mutations, modified by gene editing and differentiated in vitro into tissues of interest in conventional monolayer cultures or as 3D organoids. Thus, they provide excellent in vitro model systems for the study of the molecular and cellular basis of diseases of the nervous system.