Alessandro Rosa


Titolo Pubblicato in Anno
Selective Reduction of Ca2+ Entry Through the Human NMDA Receptor: a Quantitative Study by Simultaneous Ca2+ and Na+ Imaging MOLECULAR NEUROBIOLOGY 2024
Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties HELIYON 2024
AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE 2024
Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons CELL DEATH DISCOVERY 2023
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation LIFE SCIENCE ALLIANCE 2023
CRISPR/Cas9 and piggyBac Transposon-Based Conversion of a Pathogenic Biallelic TBCD Variant in a Patient-Derived iPSC Line Allows Correction of PEBAT-Related Endophenotypes INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Collective behavior and self-organization in neural rosette morphogenesis FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2023
The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons CELL DEATH & DISEASE 2023
Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes Methods in Molecular Biology 2022
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis STEM CELL REPORTS 2022
Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo CELL PROLIFERATION 2022
Modelling skeletal pain harnessing tissue engineering IN VITRO MODELS 2022
Emerging roles for the RNA-Binding protein HuD (ELAVL4) in nervous system diseases INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs CELL DEATH & DISEASE 2021
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor CELL DEATH & DISEASE 2021
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation SCIENCE ADVANCES 2021
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity COMMUNICATIONS BIOLOGY 2021
Editorial: The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2021
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons STEM CELL REPORTS 2021
A computational approach to investigate tdp-43 rna-recognition motif 2 c-terminal fragments aggregation in amyotrophic lateral sclerosis BIOMOLECULES 2021


  • LS1_3
  • LS2_4
  • LS3_12
  • LS3_13
  • LS5_11


  • Life-science technologies & biotechnologies

Interessi di ricerca

My field of research concerns the characterization of the molecular mechanisms that underlie cell function during differentiation and development, in order to understand how these mechanisms are altered in pathological conditions and how they can be used in therapy. In particular, my primary interest is the RNA molecule.

We use induced Pluripotent Stem Cells (iPSCs) for the study of neurodegenerative and neurodevelopmental diseases. iPSCs can be derived from patients carrying mutations, modified by gene editing and differentiated in vitro into tissues of interest in conventional monolayer cultures or as 3D organoids. Thus, they provide excellent in vitro model systems for the study of the molecular and cellular basis of diseases of the nervous system.


human induced pluripotent stem cells (hiPSC)
RNA-binding proteins
amyotrophic lateral sclerosis (ALS)
brain organoid

Laboratori di ricerca

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