Francesco Fiorentino | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity	JOURNAL OF MEDICINAL CHEMISTRY	2024
Detergents with Scalable Properties Identify Noncanonical Lipopolysaccharide Binding to Bacterial Inner Membrane Proteins	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY	2024
Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells	CHEMMEDCHEM	2024
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection	PLOS BIOLOGY	2024
(Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling	ACS INFECTIOUS DISEASES	2024
m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication	CELL REPORTS	2024
STRUCTURE-BASED MECHANISM OF RIBOREGULATION OF THE METABOLIC ENZYME SHMT1	MOLECULAR CELL	2024
Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development	PHARMACEUTICALS	2024
Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2023
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence	JOURNAL OF MEDICINAL CHEMISTRY	2023
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey	JOURNAL OF MEDICINAL CHEMISTRY	2023
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2023
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection	CELLS	2023
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation	DRUG DISCOVERY TODAY	2023
Rationalizing the Optimization of Detergents for Membrane Protein Purification	CHEMISTRY	2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8	JOURNAL OF MEDICINAL CHEMISTRY	2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.	MICROBIOLOGICAL RESEARCH	2023
The role of structural biology in the design of sirtuin activators	CURRENT OPINION IN STRUCTURAL BIOLOGY	2023
State of the art of carbonic anhydrase activators	FUTURE MEDICINAL CHEMISTRY	2023
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022

ERC

LS1_1
LS1_13
PE5_18

Keywords

medicinal chemistry

biophysical chemistry

epigenetics

antimicrobial resistance

high resolution mass spectrometry