Alessandra Pierangeli


Titolo Pubblicato in Anno
Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity MICROORGANISMS 2023
Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients MICROORGANISMS 2023
NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in Respiratory-Syncytial-Virus- and Rhinovirus-Infected Hospitalized Children PATHOGENS 2023
Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients MICROORGANISMS 2023
In Vitro Virucidal Effects of Ultraviolet Light Prototypes on RNA viruses NEW MICROBIOLOGICA 2023
Genetic diversity and its impact on disease severity in respiratory syncytial virus subtype-A and -B bronchiolitis before and after pandemic restrictions in Rome JOURNAL OF INFECTION 2023
HPV vaccination after primary treatment of HPV-related disease across different organ sites: a multidisciplinary comprehensive review and meta-analysis VACCINES 2022
Modifiable environmental factors predispose term infants to bronchiolitis but bronchiolitis itself predisposes to respiratory sequelae PEDIATRIC PULMONOLOGY 2022
Bronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelae PEDIATRIC PULMONOLOGY 2022
Distribution of Interferon Lambda 4 Single Nucleotide Polymorphism rs11322783 Genotypes in Patients with COVID-19 MICROORGANISMS 2022
The first COVID-19 lockdown resulted in most respiratory viruses disappearing among hospitalised children, with the exception of rhinoviruses ACTA PAEDIATRICA 2022
Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity EUROPEAN JOURNAL OF IMMUNOLOGY 2022
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω FRONTIERS IN IMMUNOLOGY 2022
High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis MICROBIAL PATHOGENESIS 2022
The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults CYTOKINE 2022
Low lymphocyte count: A clinical severity marker in infants with bronchiolitis PEDIATRIC PULMONOLOGY 2022
An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children FRONTIERS IN PEDIATRICS 2022
Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study AMERICAN JOURNAL OF OTOLARYNGOLOGY 2022
Common microbial genital infections and their impact on the innate immune response to HPV in cervical cells PATHOGENS 2022
High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19 CLINICAL IMMUNOLOGY 2022


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Interessi di ricerca

Caratterizzazione molecolare ed epidemiologica dei virus respiratori; il contributo della risposta immune dell’ospite alla patogenesi e alle sequele respiratorie. Di particolare rilevanza: caratterizzazione clinica e virologica di virus respiratori emergenti (Metapneumovirus, Bocavirus), del virus influenza A (H1N1) responsabile della pandemia del 2009 in malati di età  pediatrica e adulta e del Virus Respiratorio Sinciziale (RSV), con la prima rilevazione in Europa del nuovo ceppo ON1 sottotipo A, e degli altri genotipi di RSV-A e -B circolanti in Italia, in collaborazione con altri gruppi di ricerca a livello nazionale. Studio della risposta immunitaria innata e acquisita in pazienti COVID-19 e in bambini positivi a SARS-CoV-2.

Diagnosi molecolare di Papillomavirus (HPV) DNA in collaborazione coi clinici (ginecologi, dermatologi, proctologi, otorinolaringoiatri, infettivologi), rafforzamento della consapevolezza del poteziale oncogenico di HPV; epidemiologia, caratterizzazione molecolare e analisi della carica virale in infezioni da HPV con localizzazione genitale, anale, orofaringea e cutanea; attivazione di geni interferon-indotti in pazienti infetti; ruolo del microbiota nella storia naturale di HPV


Infezioni umane e sorveglianza ambientale di Enterovirus



virus respiratorio sinciziale
pneumonia: Sars-Cov-2
immunità innata

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