Mara Cirone | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms	EXPERIMENTAL HEMATOLOGY	2023
HIPK2 in Angiogenesis: A Promising Biomarker in Cancer Progression and in Angiogenic Diseases	CANCERS	2023
NRF2 and STAT3: friends or foes in carcinogenesis?	DISCOVER ONCOLOGY	2023
Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1	DISCOVER ONCOLOGY	2023
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis	VIRUS RESEARCH	2023
DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH	2022
Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation	BIOLOGY	2022
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells	VIRUS RESEARCH	2022
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells	PHARMACEUTICS	2022
The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study	BIOMOLECULES	2022
Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells	BIOMEDICINES	2022
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS	2022
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation	CARCINOGENESIS	2022
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway	BIOMEDICINES	2022
Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise	CANCERS	2022
Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF)	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress	CELL DEATH DISCOVERY	2022
The Impact of COVID-19 Infection in Cancer 2020-2021	CANCERS	2022

ERC

LS1_2
LS1_9
LS4_12
LS6
LS6_5

Interessi di ricerca

Oncoimmunologia Virale. Autofagia nella cancerogenesi virale e chimica. Target therapies e UPR e autophagy targeting nel cancro.

Keywords

Herpesvirus 4

BASI BIOLOGICHE DEL CANCRO

anti-tumor immune response

Herpesvirus 8

endoplasmic reticulum (ER stress)

Progetti di Ricerca

Exploitng the interplay between Unfolded Protein Response and DNA damage response to potentiate the efficacy of anticancer therapies
Manipulation of UPR and PRR signaling as strategy to reduce the side effects of herpesvirus-induced inflammation.
Coinvolgimento dell'autofagia nella trasformazione maligna mediata da EBV e KSHV.
Manipolazione dell'autofagia e dell'effetto Warbourg come strategia per modificare il cross-talk tra cellule tumorali KSHV-associate e microambiente tumorale
Manipulation of UPR in tumor cells and dendritic cells or macrophages exposed to tumor released factors to counteract tumor-induced immune dysfunction .