Mara Cirone | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis	VIRUSES	2018
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways	JOURNAL OF NUTRITIONAL BIOCHEMISTRY	2017
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells	CELLULAR ONCOLOGY	2017
Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice	ONCOIMMUNOLOGY	2017
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy	SCIENTIFIC REPORTS	2017
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation	CELLULAR SIGNALLING	2017
P53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2017
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells	FREE RADICAL BIOLOGY & MEDICINE	2017
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2017
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)	AUTOPHAGY	2016
High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2016
HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2	SCIENTIFIC REPORTS	2016
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression	AUTOPHAGY	2016
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma	THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY	2016
Reactivation of mutant p53 by capsaicin, the major constituent of peppers	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2016
ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose	CELL DEATH & DISEASE	2016
Hyperglycemia triggers HIPK2 protein degradation	ONCOTARGET	2016
Elevated antinuclear antibodies and altered anti-Epstein-Barr virus immune responses.	VIRUS RESEARCH	2015
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future	BIOMED RESEARCH INTERNATIONAL	2015
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH	2015

ERC

LS1_2
LS1_9
LS4_12
LS6
LS6_5

Interessi di ricerca

Oncoimmunologia Virale. Autofagia nella cancerogenesi virale e chimica. Target therapies e UPR e autophagy targeting nel cancro.

Keywords

Herpesvirus 4

BASI BIOLOGICHE DEL CANCRO

anti-tumor immune response

Herpesvirus 8

endoplasmic reticulum (ER stress)

Progetti di Ricerca

Exploitng the interplay between Unfolded Protein Response and DNA damage response to potentiate the efficacy of anticancer therapies
Manipulation of UPR and PRR signaling as strategy to reduce the side effects of herpesvirus-induced inflammation.
Coinvolgimento dell'autofagia nella trasformazione maligna mediata da EBV e KSHV.
Manipolazione dell'autofagia e dell'effetto Warbourg come strategia per modificare il cross-talk tra cellule tumorali KSHV-associate e microambiente tumorale
Manipulation of UPR in tumor cells and dendritic cells or macrophages exposed to tumor released factors to counteract tumor-induced immune dysfunction .