Mara Cirone | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis	INTERNATIONAL JOURNAL OF CANCER	2020
BFRF1 protein is involved in EBV-mediated autophagy manipulation	MICROBES AND INFECTION	2020
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway	FRONTIERS IN ONCOLOGY	2020
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)	AUTOPHAGY	2020
Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV	CELLS	2020
Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity	IUBMB LIFE	2020
EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation	AUTOPHAGY	2019
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress	JOURNAL OF GENERAL VIROLOGY	2019
Stat3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation	VIROLOGY	2019
Mutant p53 and cellular stress pathways: a criminal alliance that promotes cancer progression	CANCERS	2019
Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?	NEURAL REGENERATION RESEARCH	2019
Mutant p53, stabilized by its interplay with HSP90, activates a positive feed-back loop between NRF2 and p62 that induces chemio-resistance to Apigenin in pancreatic cancer cells	CANCERS	2019
Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response	ONCOTARGET	2019
Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy	THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY	2019
Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2019
HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells	VIRUS RESEARCH	2019
Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization	BIOMOLECULES	2019
Sourcing the immune system to induce immunogenic cell death in Kras-colorectal cancer cells	BRITISH JOURNAL OF CANCER	2019
EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3	JOURNAL OF LEUKOCYTE BIOLOGY	2018
Cytotoxic drugs activate KSHV lytic cycle in latently infected PEL cells by inducing a moderate ROS increase controlled by HSF1, NRF2 and p62/SQSTM1	VIRUSES	2018

ERC

LS1_2
LS1_9
LS4_12
LS6
LS6_5

Interessi di ricerca

Oncoimmunologia Virale. Autofagia nella cancerogenesi virale e chimica. Target therapies e UPR e autophagy targeting nel cancro.

Keywords

Herpesvirus 4

BASI BIOLOGICHE DEL CANCRO

anti-tumor immune response

Herpesvirus 8

endoplasmic reticulum (ER stress)

Progetti di Ricerca

Exploitng the interplay between Unfolded Protein Response and DNA damage response to potentiate the efficacy of anticancer therapies
Manipulation of UPR and PRR signaling as strategy to reduce the side effects of herpesvirus-induced inflammation.
Coinvolgimento dell'autofagia nella trasformazione maligna mediata da EBV e KSHV.
Manipolazione dell'autofagia e dell'effetto Warbourg come strategia per modificare il cross-talk tra cellule tumorali KSHV-associate e microambiente tumorale
Manipulation of UPR in tumor cells and dendritic cells or macrophages exposed to tumor released factors to counteract tumor-induced immune dysfunction .