Marco Lucarelli

Pubblicazioni

Titolo Pubblicato in Anno
Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
Nerve Growth Factor and the Role of Inflammation in Tumor Development CURRENT ISSUES IN MOLECULAR BIOLOGY 2024
The impact of oxidative stress on the epigenetics of fetal alcohol spectrum disorders ANTIOXIDANTS 2024
Blood count and renal functionality assessments in the emergency section disclose morbidity and ortality in omicron COVID-19 patients: a retrospective study CLINICS AND PRACTICE 2024
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency NUTRIENTS 2024
Acute diverticulitis: beyond the diagnosis: predictive role of CT in assessing risk of recurrence and clinical implications in non-operative management of acute diverticulitis LA RADIOLOGIA MEDICA 2024
Sperm DNA Fragmentation and Sperm-Borne miRNAs: Molecular Biomarkers of Embryo Development? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome BIOMEDICINES 2023
Blood Biomarkers from the Emergency Department Disclose Severe Omicron COVID-19-Associated Outcomes MICROORGANISMS 2023
The Impact of ROS and NGF in the Gliomagenesis and their Emerging Implications in the Glioma Treatment CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS 2023
The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study ANTIOXIDANTS 2023
Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Quantitative evaluation of CFTR gene expression: a comparison between relative quantification by real-time PCR and absolute quantification by droplet digital PCR GENES 2023
Investigating biomarkers for COVID-19 morbidity and mortality CURRENT TOPICS IN MEDICINAL CHEMISTRY 2023
L1077P CFTR pathogenic variant function rescue by Elexacaftor-Tezacaftor-Ivacaftor in cystic fibrosis patient-derived air-liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients RESPIRATORY RESEARCH 2023
Nerve growth factor and autoimmune diseases CURRENT ISSUES IN MOLECULAR BIOLOGY 2023
In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells ISCIENCE 2023
Amyloidogenic and Neuroinflammatory Molecular Pathways Are Contrasted Using Menaquinone 4 (MK4) and Reduced Menaquinone 7 (MK7R) in Association with Increased DNA Methylation in SK-N-BE Neuroblastoma Cell Line CELLS 2023
Early routine biomarkers of SARS-CoV-2 morbidity and mortality: outcomes from an emergency section DIAGNOSTICS 2022
Safety of multiple vaccinations and durability of vaccine‐induced antibodies in an Italian military cohort 5 years after immunization BIOMEDICINES 2022

ERC

  • LS1_3
  • LS2_2
  • LS2_3
  • LS2_4
  • LS2_14
  • LS3_12
  • LS3_13

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

- regulation of DNA methylation and demethylation processes in eukaryotic cells;

- DNA methylation, modulation of gene expression and cell differentiation;

- molecular mechanisms of the gene therapy by small fragment homologous replacement (SFHR);

- molecular genetics of cystic fibrosis and of CFTR-related disorders and study of the genotype/phenotype relationship in this diseases;

- theratyping of cystic fibrosis;

- functional characterization of CFTR (cystic fibrosis transmembrane conductance regulator) and ENaC (epithelial sodium channel) genes in physiologic and pathologic conditions;

- molecular diagnostic methodologies and pathogenetic mechanisms underlying cystic fibrosis, CFTR-related disorders, atherosclerosis, alcohol addiction and neurological disorders;

- setup and automation of mutational search methodologies.

Keywords

cystic fibrosis
DNA methylation
Personalized therapy
gene editing

Laboratori di ricerca

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