Aurelia Rughetti

Pubblicazioni

Titolo Pubblicato in Anno
DNA damage response and repair (DDR) gene mutations as an alternative mechanism to generate high TMB in never smoker NSCLC patients ANNALS OF ONCOLOGY 2022
Polymeric nanoparticles decorated with monoclonal antibodies: a new immobilization strategy for increasing lipase activity CATALYSTS 2021
The role of soluble LAG3 and soluble immune checkpoints profile in advanced head and neck cancer: a pilot study JOURNAL OF PERSONALIZED MEDICINE 2021
Immunogenic cell death and immunomodulatory effects of cabozantinib FRONTIERS IN ONCOLOGY 2021
Multicentre harmonisation of a six-colour flow cytometry panel for naïve/memory T cell immunomonitoring JOURNAL OF IMMUNOLOGY RESEARCH 2020
Immunohistochemical characterization of immune infiltrate in tumor microenvironment of glioblastoma JOURNAL OF PERSONALIZED MEDICINE 2020
Exploratory pilot study of circulating biomarkers in metastatic renal cell carcinoma CANCERS 2020
Investigating patterns of immune interaction in ovarian cancer: probing the O-glycoproteome by the macrophage galactose-like C-type Lectin (MGL) CANCERS 2020
Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients JOURNAL OF PERSONALIZED MEDICINE 2020
IgM-Rheumatoid factor confers primary resistance to anti-PD-1 immunotherapies in NSCLC patients by reducing CD137 + T-cells EBIOMEDICINE 2020
IgM-rheumatoid factor as a novel biomarker for a reduced survival in anti-PD-1 treated NSCLC patients through the decrease of CD137+T-cells ANNALS OF ONCOLOGY 2020
Bevacizumab-based chemotherapy triggers Immunological effects in responding multi-treated recurrent ovarian cancer patients by favoring the recruitment of effector T Cell Subsets JOURNAL OF CLINICAL MEDICINE 2019
Gene expression profiles of antigenic proteins of third stage larvae of the zoonotic nematode Anisakis pegreffii in response to temperature conditions PARASITE 2019
Anisakis pegreffii impacts differentiation and function of human dendritic cells PARASITE IMMUNOLOGY 2018
TK inhibitor pazopanib primes DCs by downregulation of the β-catenin pathway CANCER IMMUNOLOGY RESEARCH 2018
The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer. A meta-analysis GYNECOLOGIC ONCOLOGY 2018
The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one CANCER TREATMENT REVIEWS 2018
Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells FRONTIERS IN IMMUNOLOGY 2018
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines JOURNAL OF EXTRACELLULAR VESICLES 2018
Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells FRONTIERS IN IMMUNOLOGY 2017

ERC

  • LS1_6
  • LS2_10
  • LS2_15
  • LS4_12
  • LS6
  • LS6_3
  • LS6_10
  • LS7_14

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

  • Dendritic cells and antigen processing and presentation: extracellular vesicles and impact on tumor antigen immunogenicity and antitumor immune response
  • Role in the tumor microenvironment of Tumor glycan C-type lectin interactions: balancing immune activation and immunesuppression.
  • Target therapy and immune off target effects: Immunogenic cell death and antitumor immune response
  • Network medicine: novel approach for integrating clinical and biological data for patient outcome predictors
  • Impact of nematode A.pegreffi on antigen presenting cells function

Keywords

dendritic cells
antigen processing and presentation
Cancer vaccines
lectins
tumor antigen
Extracellular Vesicles
anti-tumor immune response
tumor microenvironment
Network medicine
glioblastoma (GBM)
breast cancer
immunogenic cell death (ICD)
ovarian cancer

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