Aurelia Rughetti

Pubblicazioni

Titolo Pubblicato in Anno
A network approach to define the predictive role of immune profile on tumor response and toxicity of anti PD-1 single agent immunotherapy in patients with solid tumors FRONTIERS IN IMMUNOLOGY 2023
Protection of gender health and fight against gender violence during the COVID-19 pandemic: the experience of our street clinic in a disadvantaged suburb of Rome Metropolitan City BMC WOMEN'S HEALTH 2023
Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs JOURNAL OF TRANSLATIONAL MEDICINE 2023
Circulating CD137+ T cell subsets and MDCSs as immune biomarkers for response to anti-PD1 immunotherapy in NSCLC patients AICC INTERNATIONAL MEETING – TRANSLATIONAL AND PRECISION MEDICINE 2023
Circulating CD137 + T cells correlate with improved response to anti-PD1 immunotherapy in cancer patients CLINICAL CANCER RESEARCH 2022
Immune effects of CDK4/6 inhibitors in patients with HR+/HER2− metastatic breast cancer: relief from immunosuppression is associated with clinical response EBIOMEDICINE 2022
Glycan-Lectin Interactions as Novel Immunosuppression Drivers in Glioblastoma INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Soluble PD-L1 as a prognostic factor for Immunotherapy treatment in solid tumors: Systematic review and Meta-Analysis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
De novo transcriptome assembly and annotation of the third stage larvae of the zoonotic parasite anisakis pegreffii BMC RESEARCH NOTES 2022
DNA damage response and repair (DDR) gene mutations as an alternative mechanism to generate high TMB in never smoker NSCLC patients ANNALS OF ONCOLOGY 2022
Polymeric nanoparticles decorated with monoclonal antibodies: a new immobilization strategy for increasing lipase activity CATALYSTS 2021
The role of soluble LAG3 and soluble immune checkpoints profile in advanced head and neck cancer: a pilot study JOURNAL OF PERSONALIZED MEDICINE 2021
Immunogenic cell death and immunomodulatory effects of cabozantinib FRONTIERS IN ONCOLOGY 2021
Multicentre harmonisation of a six-colour flow cytometry panel for naïve/memory T cell immunomonitoring JOURNAL OF IMMUNOLOGY RESEARCH 2020
Immunohistochemical characterization of immune infiltrate in tumor microenvironment of glioblastoma JOURNAL OF PERSONALIZED MEDICINE 2020
Exploratory pilot study of circulating biomarkers in metastatic renal cell carcinoma CANCERS 2020
Investigating patterns of immune interaction in ovarian cancer: probing the O-glycoproteome by the macrophage galactose-like C-type Lectin (MGL) CANCERS 2020
Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients JOURNAL OF PERSONALIZED MEDICINE 2020
IgM-Rheumatoid factor confers primary resistance to anti-PD-1 immunotherapies in NSCLC patients by reducing CD137 + T-cells EBIOMEDICINE 2020
IgM-rheumatoid factor as a novel biomarker for a reduced survival in anti-PD-1 treated NSCLC patients through the decrease of CD137+T-cells ANNALS OF ONCOLOGY 2020

ERC

  • LS1_6
  • LS2_10
  • LS2_15
  • LS4_12
  • LS6
  • LS6_3
  • LS6_10
  • LS7_14

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

  • Dendritic cells and antigen processing and presentation: extracellular vesicles and impact on tumor antigen immunogenicity and antitumor immune response
  • Role in the tumor microenvironment of Tumor glycan C-type lectin interactions: balancing immune activation and immunesuppression.
  • Target therapy and immune off target effects: Immunogenic cell death and antitumor immune response
  • Network medicine: novel approach for integrating clinical and biological data for patient outcome predictors
  • Impact of nematode A.pegreffi on antigen presenting cells function

Keywords

dendritic cells
antigen processing and presentation
Cancer vaccines
lectins
tumor antigen
Extracellular Vesicles
anti-tumor immune response
tumor microenvironment
Network medicine
glioblastoma (GBM)
breast cancer
immunogenic cell death (ICD)
ovarian cancer

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