Gian Gaetano Tartaglia

Pubblicazioni

Titolo Pubblicato in Anno
Proteome-wide observation of the phenomenon of life on the edge of solubility PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2020
BacFITBase: A database to assess the relevance of bacterial genes during host infection NUCLEIC ACIDS RESEARCH 2020
RNA-centric approaches to study RNA-protein interactions in vitro and in silico METHODS 2020
CROSSalive: A web server for predicting the in vivo structure of RNA molecules BIOINFORMATICS 2020
Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition CANCER RESEARCH 2020
Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing RNA 2020
Insights on protein thermal stability: a graph representation of molecular interactions BIOINFORMATICS 2019
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism NUCLEIC ACIDS RESEARCH 2019
RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data NUCLEIC ACIDS RESEARCH 2019
RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43 JOURNAL OF MOLECULAR BIOLOGY 2019
Phase separation drives X-chromosome inactivation: a hypothesis NATURE STRUCTURAL & MOLECULAR BIOLOGY 2019
Homage to Chris Dobson FRONTIERS IN MOLECULAR BIOSCIENCES 2019
A metastable subproteome underlies inclusion formation in muscle proteinopathies ACTA NEUROPATHOLOGICA COMMUNICATIONS 2019
The mutational landscape of a prion-like domain NATURE COMMUNICATIONS 2019
RNA structure drives interaction with proteins NATURE COMMUNICATIONS 2019
Assembly of Proteins by Free RNA during the Early Phase of Proteostasis Stress JOURNAL OF PROTEOME RESEARCH 2019
Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study PARKINSONISM & RELATED DISORDERS 2019
Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1 EMBO REPORTS 2019
Post-transcriptional regulatory patterns revealed by protein-RNA interactions SCIENTIFIC REPORTS 2019
Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs NUCLEIC ACIDS RESEARCH 2018

ERC

  • LS1
  • LS2_1

Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Progetti di Ricerca

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