Gian Gaetano Tartaglia


Titolo Pubblicato in Anno
The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates BIOINFORMATICS 2023
FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
New lessons on TDP‐43 from old N. furzeri killifish AGING CELL 2022
Prediction of Time Series Gene Expression and Structural Analysis of Gene Regulatory Networks Using Recurrent Neural Networks ENTROPY 2022
Thermometer: a webserver to predict protein thermal stability BIOINFORMATICS 2022
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes SCIENTIFIC REPORTS 2022
Phase separation drives X-chromosome inactivation NATURE STRUCTURAL & MOLECULAR BIOLOGY 2022
TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration NUCLEIC ACIDS RESEARCH 2022
Mid-infrared nanospectroscopy of individual DNA-binding protein oligomers 2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) 2022
Probing TDP-43 condensation using an in silico designed aptamer NATURE COMMUNICATIONS 2022
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
A computational approach to investigate tdp-43 rna-recognition motif 2 c-terminal fragments aggregation in amyotrophic lateral sclerosis BIOMOLECULES 2021
catRAPID omics v2.0: going deeper and wider in the prediction of protein–RNA interactions NUCLEIC ACIDS RESEARCH 2021
DualSeqDB: the host-pathogen dual RNA sequencing database for infection processes NUCLEIC ACIDS RESEARCH 2021
RNA-protein interactions: Central players in coordination of regulatory networks BIOESSAYS 2021
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins NUCLEIC ACIDS RESEARCH 2021
The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies JOURNAL OF MOLECULAR BIOLOGY 2021
Aggregation is a context-dependent constraint on protein evolution FRONTIERS IN MOLECULAR BIOSCIENCES 2021
Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade CELL DEATH & DISEASE 2020


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Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Laboratori di ricerca

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