Gian Gaetano Tartaglia | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides	FRONTIERS IN MOLECULAR BIOSCIENCES	2024
Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain	JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL	2024
Prediction of protein-RNA interactions from single-cell transcriptomic data	NUCLEIC ACIDS RESEARCH	2024
Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties	HELIYON	2024
m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication	CELL REPORTS	2024
Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments	CHEMICAL REVIEWS	2024
STRUCTURE-BASED MECHANISM OF RIBOREGULATION OF THE METABOLIC ENZYME SHMT1	MOLECULAR CELL	2024
CyCoNP lncRNA establishes cis and trans RNA-RNA interactions to supervise neuron physiology	NUCLEIC ACIDS RESEARCH	2024
Transcriptional and epigenetic characterization of a new in vitro platform to model the formation of human pharyngeal endoderm	GENOME BIOLOGY	2024
Osmolyte-induced protein stability changes explained by graph theory	COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL	2024
The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates	BIOINFORMATICS	2023
FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
RNA sequestration driven by amyloid formation: the alpha synuclein case	NUCLEIC ACIDS RESEARCH	2023
Single-photon microscopy to study biomolecular condensates	NATURE COMMUNICATIONS	2023
New lessons on TDP‐43 from old N. furzeri killifish	AGING CELL	2022
Prediction of Time Series Gene Expression and Structural Analysis of Gene Regulatory Networks Using Recurrent Neural Networks	ENTROPY	2022
Thermometer: a webserver to predict protein thermal stability	BIOINFORMATICS	2022
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes	SCIENTIFIC REPORTS	2022
Phase separation drives X-chromosome inactivation	NATURE STRUCTURAL & MOLECULAR BIOLOGY	2022
TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration	NUCLEIC ACIDS RESEARCH	2022

ERC

LS1
LS2_1

Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders. My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS). We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins. One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Progetti di Ricerca

Sequenziamento di lunghe molecole di DNA/RNA per lo studio di organismi modello e non modello

Laboratori di ricerca

CU026 ps1 35 Biologia Molecolare

CU026 ps1 35b colture cellulari