Gian Gaetano Tartaglia


Titolo Pubblicato in Anno
Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides FRONTIERS IN MOLECULAR BIOSCIENCES 2024
Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL 2024
Prediction of protein-RNA interactions from single-cell transcriptomic data NUCLEIC ACIDS RESEARCH 2024
Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties HELIYON 2024
m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication CELL REPORTS 2024
Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments CHEMICAL REVIEWS 2024
The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates BIOINFORMATICS 2023
FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
RNA sequestration driven by amyloid formation: the alpha synuclein case NUCLEIC ACIDS RESEARCH 2023
Single-photon microscopy to study biomolecular condensates NATURE COMMUNICATIONS 2023
New lessons on TDP‐43 from old N. furzeri killifish AGING CELL 2022
Prediction of Time Series Gene Expression and Structural Analysis of Gene Regulatory Networks Using Recurrent Neural Networks ENTROPY 2022
Thermometer: a webserver to predict protein thermal stability BIOINFORMATICS 2022
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes SCIENTIFIC REPORTS 2022
Phase separation drives X-chromosome inactivation NATURE STRUCTURAL & MOLECULAR BIOLOGY 2022
TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration NUCLEIC ACIDS RESEARCH 2022
Mid-infrared nanospectroscopy of individual DNA-binding protein oligomers 2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) 2022
Probing TDP-43 condensation using an in silico designed aptamer NATURE COMMUNICATIONS 2022
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021


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Interessi di ricerca

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

Laboratori di ricerca

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