Lucia Di Marcotullio | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)	EXPERT OPINION ON THERAPEUTIC PATENTS	2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth	MOLECULAR ONCOLOGY	2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation	CELL DEATH & DISEASE	2020
Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors	CANCER IMMUNOLOGY RESEARCH	2020
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma	EXPERT OPINION ON THERAPEUTIC TARGETS	2020
Dual smo/braf inhibition by flavonolignans from silybum marianum†	ANTIOXIDANTS	2020
Dubs activating the hedgehog signaling pathway: a promising therapeutic target in cancer	CANCERS	2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation	INTERNATIONAL JOURNAL OF ONCOLOGY	2019
P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation	THE FASEB JOURNAL	2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains CRC progression and chemoresistance	CANCER RESEARCH	2019
Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch	CELLS	2019
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth	CANCERS	2019
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2	ONCOGENESIS	2019
Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2019
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma	CELL COMMUNICATION AND SIGNALING	2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2018
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis	NATURE COMMUNICATIONS	2018
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors	CELL DEATH & DISEASE	2018

Progetti di Ricerca

Oncogenic role of the aminopeptidase ERAP1 in Hedgehog-dependent cancer