Lucia Di Marcotullio


Titolo Pubblicato in Anno
Potential of a natural compound as Hedgehog pathway inhibitor for the treatment of Intrahepatic Cholangiocarcinoma 30° CONGRESSO NAZIONALE DELLE MALATTIE DIGESTIVE 2024
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors NEOPLASIA 2023
Exploring the potential of anthraquinone-based hybrids for  identifying a novel generation of antagonists for the Smoothened receptor in HH-dependent tumour CHEMISTRY 2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma CELL DEATH AND DIFFERENTIATION 2023
ERAP1 as an emerging therapeutic target for medulloblastoma TRENDS IN CANCER 2022
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors? FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma CANCER LETTERS 2021
Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors CHEMISTRY-A EUROPEAN JOURNAL 2021
Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis FRONTIERS IN MOLECULAR NEUROSCIENCE 2021
SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples ELIFE 2021
Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma FRONTIERS IN CHEMISTRY 2021
A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i CANCERS 2020
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present) EXPERT OPINION ON THERAPEUTIC PATENTS 2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth MOLECULAR ONCOLOGY 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors CANCER IMMUNOLOGY RESEARCH 2020

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