Lucia Di Marcotullio

Pubblicazioni

Titolo Pubblicato in Anno
Potential of a natural compound as Hedgehog pathway inhibitor for the treatment of Intrahepatic Cholangiocarcinoma 30° CONGRESSO NAZIONALE DELLE MALATTIE DIGESTIVE 2024
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer BIOORGANIC CHEMISTRY 2024
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation ONCOGENE 2024
Dissecting the hindrance of Hedgehog pathway in Intrahepatic Cholangiocarcinoma: a step towards targeted therapy UNITED EUROPEAN GASTROENTEROLOGY JOURNALUNITED EUROPEAN GASTROENTEROLOGY JOURNAL 2024
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation CELL DEATH DISCOVERY 2024
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors NEOPLASIA 2023
Exploring the potential of anthraquinone-based hybrids for  identifying a novel generation of antagonists for the Smoothened receptor in HH-dependent tumour CHEMISTRY 2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma CELL DEATH AND DIFFERENTIATION 2023
ERAP1 as an emerging therapeutic target for medulloblastoma TRENDS IN CANCER 2022
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors? FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma CANCER LETTERS 2021
Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors CHEMISTRY-A EUROPEAN JOURNAL 2021
Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis FRONTIERS IN MOLECULAR NEUROSCIENCE 2021
SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples ELIFE 2021
Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma FRONTIERS IN CHEMISTRY 2021
A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i CANCERS 2020

Progetti di Ricerca

Laboratori di ricerca

IMAGING FUNZIONALE IN VIVO
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 202
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 220 221

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