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lucia.dimarcotullio@uniroma1.it
Lucia Di Marcotullio
Professore Ordinario
Struttura:
DIPARTIMENTO DI MEDICINA MOLECOLARE
E-mail:
lucia.dimarcotullio@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Potential of a natural compound as Hedgehog pathway inhibitor for the treatment of Intrahepatic Cholangiocarcinoma
30° CONGRESSO NAZIONALE DELLE MALATTIE DIGESTIVE
2024
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer
BIOORGANIC CHEMISTRY
2024
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
ONCOGENE
2024
Dissecting the hindrance of Hedgehog pathway in Intrahepatic Cholangiocarcinoma: a step towards targeted therapy
UNITED EUROPEAN GASTROENTEROLOGY JOURNALUNITED EUROPEAN GASTROENTEROLOGY JOURNAL
2024
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation
CANCER LETTERS
2023
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
NEOPLASIA
2023
Exploring the potential of anthraquinone-based hybrids for identifying a novel generation of antagonists for the Smoothened receptor in HH-dependent tumour
CHEMISTRY
2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma
CELL DEATH AND DIFFERENTIATION
2023
ERAP1 as an emerging therapeutic target for medulloblastoma
TRENDS IN CANCER
2022
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma
NEUROPATHOLOGY & APPLIED NEUROBIOLOGY
2022
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma
CANCER LETTERS
2021
Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors
CHEMISTRY-A EUROPEAN JOURNAL
2021
Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis
FRONTIERS IN MOLECULAR NEUROSCIENCE
2021
SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples
ELIFE
2021
Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma
FRONTIERS IN CHEMISTRY
2021
A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module
CELL REPORTS
2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i
CANCERS
2020
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)
EXPERT OPINION ON THERAPEUTIC PATENTS
2020
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Progetti di Ricerca
Oncogenic role of the aminopeptidase ERAP1 in Hedgehog-dependent cancer
Laboratori di ricerca
IMAGING FUNZIONALE IN VIVO
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 202
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 220 221
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