Lucia Di Marcotullio | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Design, palladium-catalyzed synthesis, and biological investigation of 2-substituted 3-aroylquinolin-4(1H)-ones as inhibitors of the Hedgehog signaling pathway.	JOURNAL OF MEDICINAL CHEMISTRY	2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.	SCIENTIFIC REPORTS	2017
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma	ONCOGENE	2017
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway	CELL DEATH & DISEASE	2017
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells	BMC CANCER	2017
Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects	AMERICAN JOURNAL OF HUMAN GENETICS	2017
Targeting Gli acetylation in Shh-medulloblastoma: A successful preclinical approach	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE	2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma	SCIENTIFIC REPORTS	2017
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2016
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint	ONCOTARGET	2016
MK-4101 - a potent inhibitor of the hedgehog pathway - is highly active against medulloblastoma and basal cell carcinoma	MOLECULAR CANCER THERAPEUTICS	2016
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype	CELL DEATH & DISEASE	2016
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development	EMBO JOURNAL	2016
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors	EMBO JOURNAL	2015
Digging a hole under Hedgehog: Downstream inhibition as an emerging anticancer strategy	BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER	2015
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress	CELL DEATH AND DIFFERENTIATION	2015
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth	DEVELOPMENTAL CELL	2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer	JOURNAL OF MEDICINAL CHEMISTRY	2015
Insights into gli factors ubiquitylation methods	Methods in Molecular Biology	2015
Targeting GLI factors to inhibit the Hedgehog pathway	TRENDS IN PHARMACOLOGICAL SCIENCES	2015

Progetti di Ricerca

Oncogenic role of the aminopeptidase ERAP1 in Hedgehog-dependent cancer