Eleonora Palma | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex	ACTA NEUROPATHOLOGICA	2024
Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients	MEMBRANES	2024
Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug	BRITISH JOURNAL OF PHARMACOLOGY	2024
Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimer’s disease-like neuropathology in a mouse model for Down syndrome	ANTIOXIDANTS	2023
Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models	INFLAMMATION AND REGENERATION	2023
Correction: Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models	INFLAMMATION AND REGENERATION	2023
Traditional and Innovative Anti-seizure Medications Targeting Key Physiopathological Mechanisms: Focus on Neurodevelopment and Neurodegeneration	CURRENT NEUROPHARMACOLOGY	2023
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies	NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY	2022
Lipid mediator n-3 docosapentaenoic acid-derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G-protein-coupled receptor	THE FASEB JOURNAL	2022
Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity	BIOMEDICINES	2022
Classical and Unexpected Effects of Ultra-Micronized {PEA} in Neuromuscular Function	BIOMOLECULES	2022
Unexpected Effect of IL-1beta on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia	BRAIN SCIENCES	2022
Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study	FRONTIERS IN PHARMACOLOGY	2022
Alzheimer's Disease with Epileptiform EEG Activity: Abnormal Cortical Sources of Resting State Delta Rhythms in Patients with Amnesic Mild Cognitive Impairment	JOURNAL OF ALZHEIMER'S DISEASE	2022
GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β	SCIENTIFIC REPORTS	2022
GABAergic neurotransmission in human tissues is modulated by cannabidiol	LIFE	2022
Dissecting the molecular determinants of GABAA receptors current rundown, a hallmark of refractory human epilepsy	BRAIN SCIENCES	2021
An unbalanced synaptic transmission: Cause or consequence of the amyloid oligomers neurotoxicity?	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Phytocannabinoids in neurological diseases: could they restore a physiological gabaergic transmission?	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism	PARKINSONISM & RELATED DISORDERS	2020

ERC

LS5
LS5_1
LS5_3

Interessi di ricerca

Recent research: -Study of the basic mechanisms in human epilepsies.

-Study of ligand-gated ion channels involvement in different forms of human and experimental epilepsies.

-Study of the role of GABA in seizures and of new therapeutic approaches.

-Role of altered neurotransmission in the neurodevelopmental diseases

-Role of nicotinic acetylcholine receptors in neuromuscular diseases (i.e., ALS)

Keywords

Electrophysiology

gaba receptors

Acetylcholine receptor

drug resistant epilepsy

amyotrophic lateral sclerosis

neurodevelopmental disorders

Progetti di Ricerca

Gruppi di ricerca

Gruppo di ricerca sulla sclerosi laterale amiotrofica

Laboratori di ricerca

Laboratorio di elettrofisiologia 4 — oociti (Dipartimento Fisiologia & Farmacologia – CU027)