Cecilia Battistelli

Pubblicazioni

Titolo Pubblicato in Anno
Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response JOURNAL OF HEPATOLOGY 2021
A novel RNA-based approach to counteract EMT ONCOSCIENCE 2021
Editorial: Natural Product Epigenetic Modulators and Inhibitors FRONTIERS IN PHARMACOLOGY 2021
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis FRONTIERS IN PHARMACOLOGY 2020
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells ACS MEDICINAL CHEMISTRY LETTERS 2020
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis CELL DEATH & DISEASE 2020
Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation SCIENTIFIC REPORTS 2020
The innovative potential of selenium-containing agents for fighting cancer and viral infections DRUG DISCOVERY TODAY 2020
Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition CANCER RESEARCH 2020
Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors CANCER IMMUNOLOGY RESEARCH 2020
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells CLINICAL EPIGENETICS 2019
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases FRONTIERS IN PHARMACOLOGY 2019
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation CELL DEATH & DISEASE 2019
In vivo Bioluminescence-Based Monitoring of Liver Metastases from Colorectal Cancer: An Experimental Model JOURNAL OF MICROSCOPY AND ULTRASTRUCTURE 2019
SMO inhibition modulates cellular plasticity and invasiveness in colorectal cancer FRONTIERS IN PHARMACOLOGY 2018
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets NATURE COMMUNICATIONS 2018
Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties LIVER INTERNATIONAL 2018

ERC

  • LS1
  • LS1_1
  • LS1_3
  • LS1_9
  • LS1_13
  • LS3_3
  • LS3_4
  • LS3_9
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I am interested in molecular mechanisms controlling cell plasticity. In particular I focused my investigation on mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination. My collaborators and I elucidated the role of MyoD in the control of p57 (a cyclin-dependent kinase inhibitor) during muscle differentiation through the direct binding to the chromatin, and of CTCF in the reorganization of chromatin structure in the same phenomenon. In three recent studies, I projected, developed and then elucidated with my team members the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, I found that this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. Then I focused on its transcriptional regulation, mainly mediated by another transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently I designed a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.

I am presently involved in research projects related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. In this scenario I am also investigating the role of epitranscriptomics in modulating microRNA-protein interaction both in epithelial-to- mesenchymal transition and during differentiation.

Moreover, I have been implicated in the development and biological application of different epigenetic drugs able to modulate gene expression both in epithelial-to-mesenchymal transition and in tumorigenesis. With respect to this aspect, I focused on the use different inhibitors of chromatin modifiers (DNA methyltransferases, Histone deacetylases, Polycomb repressive complex 2) in order to verify whether they could restore epithelial cell features (and epithelial genes expression rescue) without affecting transcription factor binding to the promoters of several epithelial genes.

Keywords

epigenetics
chromatin
ncRNAs
cell differentiation
tumorigenesis
liver cancer

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