Cecilia Battistelli

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal OPEN ACCESS SCIENTIFIC REPORTS 2018
The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter ONCOTARGET 2018
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation CELL DEATH AND DIFFERENTIATION 2018
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma BIOMED RESEARCH INTERNATIONAL 2017
Targeting of polycombs to DNA in EMT ONCOTARGET 2017
Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 2017
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition ONCOGENE 2017
In vivo bioluminescence-based monitoring of liver metastases from colorectal cancer: An experimental model JOURNAL OF MICROSCOPY AND ULTRASTRUCTURE 2017
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition ONCOGENE 2017
Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes STEM CELLS INTERNATIONAL 2016
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis STEM CELLS INTERNATIONAL 2016
The lncRNA HOTAIR links the repressor Snail to epigenetic modifications of specific genomic sites in Epithelial-to-Mesenchymal Transition FISV - Federazione Italiana Scienze della Vita Program and Abstracts of the XIV FISV CONGRESS 2016
The RNA binding protein SYNCRIP controls microRNAs sorting in exosomes FISV - Federazione Italiana Scienze della Vita Program and Abstracts of the XIV FISV CONGRESS 2016
A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells EPIGENETICS 2016
The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting CELL REPORTS 2016
SETDB1 is a new promising target in HCC therapy CHINESE CLINICAL ONCOLOGY 2016
Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29 BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS 2015
A lncRNA-mediated interaction between Snail and Ezh2 governs epigenetic modifications causal to EMT of the hepatocyte 2015
A lncRNA-mediated interaction between Snail and Ezh2 governs epigenetic modifications causal to EMT of the hepatocyte ABCD congress 2015, The biennial congress of italian association of cell biology and differentiation 2015
A lncRNA-mediated interaction between Snail and Ezh2 governs epigenetic modifications causal to EMT of the hepatocyte 2015

ERC

  • LS1
  • LS1_1
  • LS1_3
  • LS1_9
  • LS1_13
  • LS3_3
  • LS3_4
  • LS3_9
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I am interested in molecular mechanisms controlling cell plasticity. In particular I focused my investigation on mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination. My collaborators and I elucidated the role of MyoD in the control of p57 (a cyclin-dependent kinase inhibitor) during muscle differentiation through the direct binding to the chromatin, and of CTCF in the reorganization of chromatin structure in the same phenomenon. In three recent studies, I projected, developed and then elucidated with my team members the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, I found that this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. Then I focused on its transcriptional regulation, mainly mediated by another transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently I designed a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.

I am presently involved in research projects related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. In this scenario I am also investigating the role of epitranscriptomics in modulating microRNA-protein interaction both in epithelial-to- mesenchymal transition and during differentiation.

Moreover, I have been implicated in the development and biological application of different epigenetic drugs able to modulate gene expression both in epithelial-to-mesenchymal transition and in tumorigenesis. With respect to this aspect, I focused on the use different inhibitors of chromatin modifiers (DNA methyltransferases, Histone deacetylases, Polycomb repressive complex 2) in order to verify whether they could restore epithelial cell features (and epithelial genes expression rescue) without affecting transcription factor binding to the promoters of several epithelial genes.

Keywords

epigenetics
chromatin
ncRNAs
cell differentiation
tumorigenesis
liver cancer

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