Cecilia Battistelli

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2024
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease JOURNAL OF MEDICINAL CHEMISTRY 2024
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity CELL DEATH & DISEASE 2023
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity CELL DEATH & DISEASE 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Interaction of Garcinia cambogia (Gaertn.) Desr. and Drugs as a Possible Mechanism of Liver Injury: The Case of Montelukast ANTIOXIDANTS 2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2023
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Next RNA therapeutics: the mine of non-coding INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
A novel microRNA signature for the detection of melanoma by liquid biopsy JOURNAL OF TRANSLATIONAL MEDICINE 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
MyoD-Induced Trans-Differentiation: A Paradigm for Dissecting the Molecular Mechanisms of Cell Commitment, Differentiation and Reprogramming CELLS 2022
Selenium-Containing Agents Acting on Cancer—A New Hope? PHARMACEUTICS 2022
Persistence of fibrogenic process in direct-acting antiviral (DAA) treated patients? EXRNA 2022
lncRNA HOTAIR functions and therapeutic perspectives ONCOSCIENCE 2022
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options DRUG DISCOVERY TODAY 2021
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology FRONTIERS IN PHARMACOLOGY 2021
Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response journal of Hepatology 2021
A novel RNA-based approach to counteract EMT ONCOSCIENCE 2021

ERC

  • LS1
  • LS1_1
  • LS1_3
  • LS1_9
  • LS1_13
  • LS3_3
  • LS3_4
  • LS3_9
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I am interested in molecular mechanisms controlling cell plasticity. In particular I focused my investigation on mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination. My collaborators and I elucidated the role of MyoD in the control of p57 (a cyclin-dependent kinase inhibitor) during muscle differentiation through the direct binding to the chromatin, and of CTCF in the reorganization of chromatin structure in the same phenomenon. In three recent studies, I projected, developed and then elucidated with my team members the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, I found that this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. Then I focused on its transcriptional regulation, mainly mediated by another transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently I designed a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.

I am presently involved in research projects related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. In this scenario I am also investigating the role of epitranscriptomics in modulating microRNA-protein interaction both in epithelial-to- mesenchymal transition and during differentiation.

Moreover, I have been implicated in the development and biological application of different epigenetic drugs able to modulate gene expression both in epithelial-to-mesenchymal transition and in tumorigenesis. With respect to this aspect, I focused on the use different inhibitors of chromatin modifiers (DNA methyltransferases, Histone deacetylases, Polycomb repressive complex 2) in order to verify whether they could restore epithelial cell features (and epithelial genes expression rescue) without affecting transcription factor binding to the promoters of several epithelial genes.

Keywords

epigenetics
chromatin
ncRNAs
cell differentiation
tumorigenesis
liver cancer

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