Fabio Di Domenico | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Potential therapeutic value of the anti-diabetic drug metformin in a mouse model of Rett syndrome: a preclinical study	FENS 2020 virtual forum	2020
Multiple Herpes simplex virus-1 (HSV-1) reactivations induce protein oxidative damage in mouse brain. Novel mechanisms for Alzheimer’s disease progression	MICROORGANISMS	2020
Chronic perk induction promotes alzheimer-like neuropathology in down syndrome: Insights for therapeutic intervention	PROGRESS IN NEUROBIOLOGY	2020
The dysregulation of OGT/OGA cycle mediates Tau and APP neuropathology in down syndrome	NEUROTHERAPEUTICS	2020
Proteomics study of peripheral blood mononuclear cells in down syndrome children	ANTIOXIDANTS	2020
BVR-A deficiency leads to autophagy impairment through the dysregulation of AMPK/mTOR axis in the brain—Implications for neurodegeneration	ANTIOXIDANTS	2020
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)	AUTOPHAGY	2020
Biliverdin reductase-A mediates the beneficial effects of intranasal insulin in Alzheimer disease	MOLECULAR NEUROBIOLOGY	2019
Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease	NEUROBIOLOGY OF DISEASE	2019
Reduced biliverdin reductase-a levels are associated with early alterations of insulin signaling in obesity	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2019
Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome	REDOX BIOLOGY	2019
Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses	EXPERT REVIEW OF PROTEOMICS	2019
Targeting mitochondria in Alzheimer disease: rationale and perspectives	CNS DRUGS	2019
Metformin treatment rescues aberrant mitochondrial activity and oxidative stress status in the brain of female mouse model of Rett syndrome	6th European Conference on Behaviour and Cognition	2019
Early and selective activation and subsequent alterations to the unfolded protein response in down syndrome mouse models	JOURNAL OF ALZHEIMER'S DISEASE	2018
Poly-ubiquitin profile in Alzheimer disease brain	NEUROBIOLOGY OF DISEASE	2018
Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2018
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: implications for Alzheimer disease	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2018
Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: novel hints on immunosenescence and biomarker detection	FREE RADICAL BIOLOGY & MEDICINE	2018
Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies	EXPERT REVIEW OF NEUROTHERAPEUTICS	2018

Progetti di Ricerca

Deciphering the the interplay between the unfolded protein response and insulin resistance in Down syndrome brain
Inhibition of PERK pathway for the early treatment of Alzheimer Disease-like cognitive decline in Down Syndrome
The sweet link between aberrant brain metabolism and cognitive decline: A novel role for altered protein O-GlcNAcylation.
Deciphering the role of aberrant PERK/NRF2 axis in Down Syndrome