Fabio Di Domenico | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome	TRANSLATIONAL NEURODEGENERATION	2018
mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia	FREE RADICAL BIOLOGY & MEDICINE	2018
Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies	EXPERT REVIEW OF NEUROTHERAPEUTICS	2017
Introductory editorial: drug-eluting stents or drug-eluting grafts? insights from proteomic analysis	DRUG TARGET INSIGHTS	2017
Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of Alzheimer disease and other selected age-related neurodegenerative disorders	FREE RADICAL BIOLOGY & MEDICINE	2017
The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics	ANTIOXIDANTS & REDOX SIGNALING	2017
Polyubiquitinylation profile in down syndrome brain before and after the development of Alzheimer neuropathology	ANTIOXIDANTS & REDOX SIGNALING	2017
Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach	NEUROBIOLOGY OF AGING	2017
I principi europei sui metodi alternativi alla sperimentazione animale	Metodi alternativi alla sperimentazione animale	2017
Metodi alternativi alla sperimentazione animale		2017
From redox proteomics to clinical practice: Search for therapeutic targets	JOURNAL OF GERONTOLOGY AND GERIATRICS	2017
Increased mammalian target of rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of down's syndrome	NEURODEGENERATIVE DISEASES	2016
Impairment of biliverdin reductase-a promotes brain insulin resistance in Alzheimer disease: a new paradigm	FREE RADICAL BIOLOGY & MEDICINE	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)	AUTOPHAGY	2016
Activation of p53 in down syndrome and in the ts65dn mouse brain is associated with a pro-apoptotic phenotype	JOURNAL OF ALZHEIMER'S DISEASE	2016
Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target	MOLECULAR BIOSYSTEMS	2016
It is all about (U)biquitin: role of altered ubiquitin-proteasome system and UCHL1 in Alzheimer disease	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY	2016
Cathepsin D as a therapeutic target in Alzheimer’s disease	EXPERT OPINION ON THERAPEUTIC TARGETS	2016
Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2016
Autoantibodies profile in matching CSF and serum from AD and aMCI patients: potential pathogenic role and link to oxidative damage	CURRENT ALZHEIMER RESEARCH	2016

Progetti di Ricerca

Deciphering the the interplay between the unfolded protein response and insulin resistance in Down syndrome brain
Inhibition of PERK pathway for the early treatment of Alzheimer Disease-like cognitive decline in Down Syndrome
The sweet link between aberrant brain metabolism and cognitive decline: A novel role for altered protein O-GlcNAcylation.
Deciphering the role of aberrant PERK/NRF2 axis in Down Syndrome