Paola Pietrangeli

Pubblicazioni

Titolo Pubblicato in Anno
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain THE JOURNAL OF BIOLOGICAL CHEMISTRY 2024
The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State JOURNAL OF MOLECULAR BIOLOGY 2024
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains THE JOURNAL OF BIOLOGICAL CHEMISTRY 2023
P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents AMINO ACIDS 2023
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
An intramolecular energetic network regulates ligand recognition in a SH2 domain PROTEIN SCIENCE 2023
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2023
Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Faster and sensitive zymographic detection of oxidases generating hydrogen peroxide. The case of diamine oxidase ANALYTICAL BIOCHEMISTRY 2022
Folding and binding mechanisms of the SH2 domain from Crkl BIOMOLECULES 2022
Exploring the effect of tethered domains on the folding of Grb2 protein ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2022
SH2 Domains: Folding, Binding and Therapeutical Approaches INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Copper-containing amine oxidase purified from lathyrus sativus as a modulator of human neutrophil functions INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2020
Lathyrus sativus diamine oxidase reduces clostridium difficile toxin a-induced toxicity in caco-2 cells by rescuing rhoa-gtpase and inhibiting pp38-mapKknf-κb/hif-1α activation PHYTOTHERAPY RESEARCH 2020
Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles SCIENTIFIC REPORTS 2020
Type E botulinum neurotoxin-producing clostridium butyricum strains are aerotolerant during vegetative growth MSYSTEMS 2019
Lathyrus sativus diamine oxidase counteracts histamine-induced cell proliferation, migration and pro-angiogenic mediators release in human colon adenocarcinoma cell line caco-2 PHYTOTHERAPY RESEARCH 2019
Zymographic determination of intrinsic specific activity of oxidases in the presence of interfering proteins Protein gel detection and imaging. Methods and protocols 2018
Stability of vegetal diamine oxidase in simulated intestinal media: protective role of cholic acids JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018
Diamine oxidase from white pea (Lathyrus sativus) combined with catalase protects the human intestinal Caco-2 cell line from histamine damage APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2017

ERC

  • LS1
  • LS1_2
  • LS1_4

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Ruolo delle ammino ossidasi, ammine biogene e poliammine nella crescita e proliferazione cellulare. - Purificazione e caratterizzazione delle diammino ossidasi di origine vegetale. Studio dei parametri cinetici e correlazioni con le funzioni fisiologiche dell'enzima. - Potenziale uso terapeutico della diammino ossidasi, veicolata mediante opportune formulazioni orali,  per il trattamento delle allergie alimentari e di varie condizioni infiammatorie intestinali.

Progetti di Ricerca

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma