Laura Ottini | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Matched germline and tumor profiling in male breast cancer for the discovery of molecular subtypes with clinical relevance	Cancer ResearchCANCER RESEARCH	2020
Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants	JAMA ONCOLOGY	2020
Common susceptibility loci for male breast cancer	JOURNAL OF THE NATIONAL CANCER INSTITUTE	2020
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality	ISCIENCE	2020
Paradoxical psoriasis induced by Anti-TNFα treatment: Evaluation of disease-specific clinical and genetic markers	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
A novel BRCA2 splice variant identified in a young woman	MOLECULAR GENETICS & GENOMIC MEDICINE	2020
Epidemiology and biological characteristics of male breast cancer in Italy	BREAST CANCER	2020
Height and body mass index as modifiers of breast cancer risk in BRCA1/2 mutation carriers: a mendelian randomization study	JOURNAL OF THE NATIONAL CANCER INSTITUTE	2019
Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer	PEERJ	2019
Insight into genetic susceptibility to male breast cancer by multigene panel testing: results from a multicenter study in Italy	INTERNATIONAL JOURNAL OF CANCER	2019
MiRNAs as Potential Prognostic Biomarkers for Metastasis in Thin and Thick Primary Cutaneous Melanomas.	ANTICANCER RESEARCH	2019
Medical imaging as a taphonomic tool. The naturally-mummified bodies from Takarkori rock shelter (Tadrart Acacus, SW Libya, 6100-5600 uncal BP)	JOURNAL OF CULTURAL HERITAGE MANAGEMENT AND SUSTAINABLE DEVELOPMENT	2019
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk	ENDOCRINE CONNECTIONS	2019
Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data	PEERJ	2019
Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness	CANCER RESEARCH	2019
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers	BRITISH JOURNAL OF CANCER	2019
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer	NPJ BREAST CANCER	2019
A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy	THE BREAST	2018
Gene-specific methylation profiles in BRCA-mutation positive and BRCA-mutation negative male breast cancers	ONCOTARGET	2018
Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy	THE BREAST	2018

Progetti di Ricerca

Exploring somatic mutational landscapes of male breast cancers characterized for germline mutations in DNA repair genes.
Analysis of Tumor Mutational Burden in Male Breast Cancers characterized for germline mutations in homologous recombination genes
Exploring the transcriptional landscape of BRCA-positive and BRCA-negative male breast cancers by RNA-sequencing
Providing insights into the transcriptome profile of BRCA mutation-positive and -negative male breast cancer
New players in the Homologous Recombination pathway: investigating the role of SMYD3 in breast cancers characterized for BRCA mutation status