Laura Ottini | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
HER2-Low Expression in Male Breast Cancer: Results from a Multicenter Series in Italy	CANCERS	2024
Gender-Specific Genetic Predisposition to Breast Cancer: BRCA Genes and Beyond	CANCERS	2024
Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology	FRONTIERS IN ONCOLOGY	2023
Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study	EUROPEAN JOURNAL OF CANCER	2023
Impact of Functional Polymorphisms on Drug Survival of Biological Therapies in Patients with Moderate-to-Severe Psoriasis	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants	JOURNAL OF CLINICAL ONCOLOGY	2022
Distribution of Interferon Lambda 4 Single Nucleotide Polymorphism rs11322783 Genotypes in Patients with COVID-19	MICROORGANISMS	2022
Reply to V. Fallet et al	JOURNAL OF CLINICAL ONCOLOGY	2022
Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care	CANCERS	2022
A possible link between gut microbiome composition and cardiovascular comorbidities in psoriatic patients	JOURNAL OF PERSONALIZED MEDICINE	2022
Gut microbiome profile in psoriatic patients treated and untreated with biologic therapy	JOURNAL OF DERMATOLOGY	2021
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers	NATURE COMMUNICATIONS	2021
Bone density and genomic analysis unfold cold adaptation mechanisms of extinct inhabitants of Tierra del Fuego	SCIENTIFIC REPORTS	2021
Pre-diagnostic DNA methylation patterns differ according to mammographic breast density amongst women who subsequently develop breast cancer: a case-only study in the EPIC-Florence cohort	BREAST CANCER RESEARCH AND TREATMENT	2021
Transcriptome of male breast cancer matched with germline profiling reveals novel molecular subtypes with possible clinical relevance	CANCERS	2021
DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study	AGING CELL	2021
Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores	JOURNAL OF THE NATIONAL CANCER INSTITUTE	2021
Cancer risks associated with germline PALB2 pathogenic variants: an international study of 524 families	JOURNAL OF CLINICAL ONCOLOGY	2020
Matched germline and tumor profiling in male breast cancer for the discovery of molecular subtypes with clinical relevance	Cancer ResearchCANCER RESEARCH	2020
Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants	JAMA ONCOLOGY	2020

Progetti di Ricerca

Exploring somatic mutational landscapes of male breast cancers characterized for germline mutations in DNA repair genes.
Analysis of Tumor Mutational Burden in Male Breast Cancers characterized for germline mutations in homologous recombination genes
Exploring the transcriptional landscape of BRCA-positive and BRCA-negative male breast cancers by RNA-sequencing
Providing insights into the transcriptome profile of BRCA mutation-positive and -negative male breast cancer
New players in the Homologous Recombination pathway: investigating the role of SMYD3 in breast cancers characterized for BRCA mutation status

Laboratori di ricerca

EPIDEMIOLOGIA MOLECOLARE DEL CANCRO