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gianluca.canettieri@uniroma1.it
Gianluca Canettieri
Professore Ordinario
Struttura:
DIPARTIMENTO DI MEDICINA MOLECOLARE
E-mail:
gianluca.canettieri@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
ONCOGENE
2024
Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
NATURE COMMUNICATIONS
2024
Development of N-(4-(1 H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability
JOURNAL OF MEDICINAL CHEMISTRY
2024
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability
CANCERS
2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation
CANCER LETTERS
2023
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
2023
Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment. From synthesis to in vitro studies on neuroblastoma cell lines
JOURNAL OF COLLOID AND INTERFACE SCIENCE
2023
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
NEOPLASIA
2023
Modeling myotonic dystrophy type 2 using Drosophila melanogaster
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma
CELL DEATH AND DIFFERENTIATION
2023
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
JOURNAL OF MEDICINAL CHEMISTRY
2023
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation
CELLS
2022
Bovine serum amine oxidase and polyamine analogues: chemical synthesis and biological evaluation integrated with molecular docking and 3-D QSAR studies
JOURNAL OF CHEMICAL INFORMATION AND MODELING
2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma
NEUROPATHOLOGY & APPLIED NEUROBIOLOGY
2022
Opposite effect of thyroid hormones on oxidative stress and on mitochondrial respiration in COVID-19 patients
ANTIOXIDANTS
2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question
CANCERS
2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
2022
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2021
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5
CELLS
2021
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ERC
LS4_9
LS4_12
KET
Life-science technologies & biotechnologies
Keywords
Colorectal cancer
Medulloblastoma
cancer metabolism
Hedgehog (Hh) pathway
epigenetic
redox imbalance
biguanides
polyamine metabolism
translation
gene transcription
AMPK
C-Myc
Progetti di Ricerca
Targeting Reductive Stress-GDF15 Axis in Colorectal Cancer
Role of IRES-dependent translation of MYC in Colorectal Cancer
Gruppi di ricerca - Responsabile
EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)
Laboratori di ricerca
BIOENERGETICA
Laboratorio biochimico biologico - camera fredda
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 209
LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 227 228
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