Gianluca Canettieri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability	CANCERS	2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation	CANCER LETTERS	2023
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation	CELLS	2022
Bovine serum amine oxidase and polyamine analogues: chemical synthesis and biological evaluation integrated with molecular docking and 3-D QSAR studies	JOURNAL OF CHEMICAL INFORMATION AND MODELING	2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma	NEUROPATHOLOGY & APPLIED NEUROBIOLOGY	2022
Opposite effect of thyroid hormones on oxidative stress and on mitochondrial respiration in COVID-19 patients	ANTIOXIDANTS	2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question	CANCERS	2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor	JOURNAL OF MEDICINAL CHEMISTRY	2022
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2021
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5	CELLS	2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors	ONCOGENE	2021
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function	ELIFE	2021
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids	CELL DEATH & DISEASE	2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module	CELL REPORTS	2020
Aged garlic extract and its constituent, S-allyl-L-cysteine, induce the apoptosis of neuroblastoma cancer cells due to mitochondrial membrane depolarization	EXPERIMENTAL AND THERAPEUTIC MEDICINE	2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i	CANCERS	2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer	FRONTIERS IN ONCOLOGY	2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response	ONCOGENESIS	2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth	MOLECULAR ONCOLOGY	2020

ERC

LS4_9
LS4_12

KET

Life-science technologies & biotechnologies

Keywords

Colorectal cancer

Medulloblastoma

cancer metabolism

Hedgehog (Hh) pathway

epigenetic

redox imbalance

biguanides

polyamine metabolism

translation

gene transcription

AMPK

C-Myc

Progetti di Ricerca

Laboratori di ricerca

BIOENERGETICA

Laboratorio biochimico biologico - camera fredda

LABORATORIO BIOCHIMICO BIOLOGICO LIV BIOSICUREZZA 1 209

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