Gianluca Canettieri


Titolo Pubblicato in Anno
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability CANCERS 2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation CELLS 2022
Bovine serum amine oxidase and polyamine analogues: chemical synthesis and biological evaluation integrated with molecular docking and 3-D QSAR studies JOURNAL OF CHEMICAL INFORMATION AND MODELING 2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
Opposite effect of thyroid hormones on oxidative stress and on mitochondrial respiration in COVID-19 patients ANTIOXIDANTS 2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question CANCERS 2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor JOURNAL OF MEDICINAL CHEMISTRY 2022
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2021
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5 CELLS 2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors ONCOGENE 2021
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function ELIFE 2021
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids CELL DEATH & DISEASE 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
Aged garlic extract and its constituent, S-allyl-L-cysteine, induce the apoptosis of neuroblastoma cancer cells due to mitochondrial membrane depolarization EXPERIMENTAL AND THERAPEUTIC MEDICINE 2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i CANCERS 2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer FRONTIERS IN ONCOLOGY 2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response ONCOGENESIS 2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth MOLECULAR ONCOLOGY 2020


  • LS4_9
  • LS4_12


  • Life-science technologies & biotechnologies


Colorectal cancer
cancer metabolism
Hedgehog (Hh) pathway
redox imbalance
polyamine metabolism
gene transcription

Laboratori di ricerca

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