Ricerc@Sapienza

Di Marcotullio Lab website: 

sites.google.com/uniroma1.it/dimarcotulliolab/home

Alterations in developmental signaling pathways are crucial events in the onset and progression of cancer. Understanding the complex regulatory networks that control these pathways is crucial for the development of new and more effective therapeutic approaches. With this in mind, we aim to transition from innovative basic research to translational medicine. Our mission is to elucidate the molecular mechanisms underlying brain cancer and to deepen our understanding of its pathogenesis through a comprehensive multidisciplinary approach that integrates biochemistry, molecular and cellular assays, spatial -omics, and computational analysis.

Main research topics:

• Study of the molecular processes involved in brain development, tumorigenesis and deregulated pathways; role of ubiquitination processes in regulating protein homeostasis and the function of enzymes and proteins.
• Identification and molecular characterization of new therapeutic targets.
• Target therapy: development of new natural drugs and RNA-based therapies.
• RNA expression profiling (miRNA and mRNA) in tumors of the nervous system and in neuromuscular disorders.