Daniela De Biase


Titolo Pubblicato in Anno
On the potential role of naturally occurring carboxylic organic acids as anti-infective agents: opportunities and challenges INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2024
Multifunctional FFP2 face mask for white light disinfection and pathogens detection using hybrid nanostructures and optical metasurfaces SMALL 2024
Cascade structured plasmonic liquid crystal biosensor for the rapid detection of harmful bacteria dispersed in potable water ADVANCED SENSOR RESEARCH 2024
Antibacterial activity of peptide derivatives of phosphinothricin against multidrug-resistant Klebsiella pneumoniae MOLECULES 2023
Physical, chemical, and sensory properties of water kefir produced from Aronia melanocarpa juice and pomace FOOD CHEMISTRY X 2023
White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination JOURNAL OF MATERIALS CHEMISTRY. B 2023
A Desmethylphosphinothricin Dipeptide Derivative Effectively Inhibits Escherichia coli and Bacillus subtilis Growth BIOMOLECULES 2023
Exploitation of microbial activities at low pH to enhance planetary health FEMS MICROBIOLOGY REVIEWS 2023
EuroMicropH Open Meeting: Understanding and Exploiting the Impacts of Low pH on Micro-organisms. Programme and Abstracts EuroMicropH Open Meeting: Understanding and Exploiting the Impacts of Low pH on Micro-organisms. Programme and Abstracts 2023
Landscape of stress response and virulence genes among listeria monocytogenes strains FRONTIERS IN MICROBIOLOGY 2022
Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2022
Editorial: Microbial stress: From Model Organisms to Application in Food, Microbiotechnology and Medicine FRONTIERS IN MICROBIOLOGY 2022
Microbial stress: From model organisms to applications in food, microbiotechnology and medicine 2022
Label-free and reusable antibody-functionalized gold nanorod arrays for the rapid detection of Escherichia coli cells in a water dispersion ENVIRONMENTAL SCIENCE. NANO 2022
A COST Action on microbial responses to low pH: developing links and sharing resources across the academic-industrial divide NEW BIOTECHNOLOGY 2022
Nanotechnology-based biosensor for the detection of harmful pathogens in potable water 2021 IEEE International Workshop on Metrology for AeroSpace, MetroAeroSpace 2021 - Proceedings 2021
Stress survival islets contribute to clonal and serotype-specific differences in L. monocytogenes IOP CONFERENCE SERIES. EARTH AND ENVIRONMENTAL SCIENCE 2021
Editorial. Microbial stress. From sensing to intracellular and population responses FRONTIERS IN MICROBIOLOGY 2020
Understanding how micro-organisms respond to acid pH is central to their control and successful exploitation FRONTIERS IN MICROBIOLOGY 2020
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group COMMUNICATIONS CHEMISTRY 2020


  • LS1
  • LS6_7

Interessi di ricerca

  • Microbiology-Molecular Biology: working on the transcriptional regulation and the biochemistry of the glutamate and glutamine-dependent systems, the major acid resistance (AR) systems in Escherichia coli (commensal and pathogenic) and many other enteric bacteria. Several interconnections between different AR systems and other physiological and stress-related processes in E. coli and other bacteria are currently under investigation.
  • Biochemistry: Expert on PLP-dependent enzymes, in particular glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T) of mammalian and bacterial origin. The structural properties and the catalytic mechanism of GAD are investigated via site-directed mutagenesis, expression and purification of recombinant variants, kinetic and spectroscopic studies in combination with structural studies (the latter in collaboration).
  • Biotechnology: Exploiting and engineering GAD for biotech applications, including the synthesis of bioactive molecules. In addition she is also studying the acid stress response in E. coli and other bacterial species for applications in the food and biotech sector (vice-chair of the COST Action CA18113 “Understanding and exploiting the impacts of low pH on micro-organisms”)


antiepileptic drugs
biochemistry, genetics and molecular biology (all)
Escherichia coli protein
glutamate-dependent acid resistanc
PLP-dependent enzym

Laboratori di ricerca

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma