Marco Tripodi

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2024
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity CELL DEATH & DISEASE 2023
Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective CELL & BIOSCIENCE 2023
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity CELL DEATH & DISEASE 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2023
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Next RNA therapeutics: the mine of non-coding INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Persistence of fibrogenic process in direct-acting antiviral (DAA) treated patients? EXRNA 2022
lncRNA HOTAIR functions and therapeutic perspectives ONCOSCIENCE 2022
Mechanisms of peritoneal fibrosis: focus on immune cells-peritoneal stroma interactions FRONTIERS IN IMMUNOLOGY 2021
Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response JOURNAL OF HEPATOLOGY 2021
The RNA editing enzyme ADAR2 restricts L1 mobility RNA BIOLOGY 2021
Pleural mesothelial cells modulate the inflammatory/profibrotic response during SARS-CoV-2 infection FRONTIERS IN MOLECULAR BIOSCIENCES 2021
A novel RNA-based approach to counteract EMT ONCOSCIENCE 2021
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells ACS MEDICINAL CHEMISTRY LETTERS 2020
Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis CELL DEATH & DISEASE 2020

ERC

  • LS1
  • LS1_1
  • LS1_3
  • LS2_3
  • LS2_4
  • LS2_8
  • LS3_5
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

molecular mechanisms controlling cell plasticity. In particular focused  on mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination.  In three recent studies, we unveiled  the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, we found that  this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. With respect to its transcriptional regulation, we demonstrated that is mainly mediated by the  transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently we developed  a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.

In parallel , weare involved in a  project related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. 

 

Keywords

EMT Epithelial-Mesenchymal Transition
long non-coding RNA (lncRNA)
miRNA
RNA-protein interactions
epigenetic

Laboratori di ricerca

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