Enrico De Smaele | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Targeting Gli acetylation in Shh-medulloblastoma: A successful preclinical approach	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE	2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma	SCIENTIFIC REPORTS	2017
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.	ONCOTARGET	2016
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint	ONCOTARGET	2016
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability	JOURNAL OF CELL SCIENCE	2016
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors	EMBO JOURNAL	2015
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth	DEVELOPMENTAL CELL	2015

Principali interessi di ricerca.

- Biologia molecolare dei tumori

- medulloblastoma

- Hedgehog signalling in development and disease

- NFkB pathway and carcinogenesis

- miRNAs and cancer

KCTD proteins and cancer

Sonic hedgehog pathway

NF-kappa B

Medulloblastoma

KCTD21

KCTD15

miRNA

cancer biology