Enrico De Smaele


Titolo Pubblicato in Anno
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy CANCERS 2023
β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2023
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors NEOPLASIA 2023
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment CELL DEATH & DISEASE 2023
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice MICROBIOLOGY SPECTRUM 2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma CELL DEATH AND DIFFERENTIATION 2023
Islet regeneration and pancreatic duct glands in human and experimental diabetes FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2022
 Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo JOURNAL OF TRANSLATIONAL MEDICINE 2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2021
Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes CELL DEATH DISCOVERY 2021
Microbiological profiles of dental implants in metabolic syndrome patients: A case-control study ANTIBIOTICS 2021
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2021
The emerging role of the KCTD proteins in cancer CELL COMMUNICATION AND SIGNALING 2021
Methods for modulating the pathway of NF-κB using short hairpin RNA (ShRNA) Methods in Molecular Biology 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
From single gene analysis to single cell profiling: a new era for precision medicine JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2020
Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription NUCLEIC ACIDS RESEARCH 2020
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells SCIENTIFIC REPORTS 2020


  • LS2_3
  • LS3_1
  • LS3_5
  • LS4_12


  • Life-science technologies & biotechnologies

Interessi di ricerca

Principali interessi di ricerca.

- Biologia molecolare dei tumori

- medulloblastoma

- Hedgehog signalling in development and disease

- NFkB pathway and carcinogenesis

- miRNAs and cancer

KCTD proteins and cancer


Sonic hedgehog pathway
NF-kappa B
cancer biology

Laboratori di ricerca

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