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luisa.iacovelli@uniroma1.it
Luisa Iacovelli
Ricercatore
Struttura:
DIPARTIMENTO DI FISIOLOGIA E FARMACOLOGIA "VITTORIO ERSPAMER"
E-mail:
luisa.iacovelli@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders
NEUROPHARMACOLOGY
2023
Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice
LIFE
2022
The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia
NEUROPHARMACOLOGY
2022
mGlu3 receptor regulates microglial cell reactivity in neonatal rats
JOURNAL OF NEUROINFLAMMATION
2021
Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
NEUROPHARMACOLOGY
2021
MGlu3 receptor regulates microglial cell reactivity in neonatal rats.
JOURNAL OF NEUROINFLAMMATION
2021
The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia
SCHIZOPHRENIA BULLETIN
2020
Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia
FRONTIERS IN PSYCHIATRY
2019
Targeting metabotropic glutamate receptors in the treatment of primary brain tumors
CURRENT OPINION IN PHARMACOLOGY
2018
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system
NEUROPHARMACOLOGY
2018
Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria
FRONTIERS IN NEUROSCIENCE
2018
In vivo non-radioactive assessment of mGlu5 receptor-activated polyphosphoinositide hydrolysis in response to systemic administration of a positive allosteric modulator.
FRONTIERS IN PHARMACOLOGY
2018
Targeting metabotropic glutamate receptors in the treatment of primary brain tumors
CURRENT OPINION IN PHARMACOLOGY
2018
Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus
PHARMACOLOGICAL RESEARCH
2017
Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling
NEUROPHARMACOLOGY
2017
Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling
NEUROPHARMACOLOGY
2017
BDNF rs6265 methylation and genotype interact on risk for schizophrenia
EPIGENETICS
2016
Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
NEUROPHARMACOLOGY
2016
Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
NEUROPHARMACOLOGY
2016
Xanthurenic Acid Activates mGlu2/3 metabotropic glutamate receptors and is a potential trait marker for schizophrenia
SCIENTIFIC REPORTS
2015
Progetti di Ricerca
Studio della trasduzione del segnale e dell'effetto sulle "performance" cognitive di VU0360172 e VU0409551, 2 farmaci modulatori allosterici positivi del recettore metabotropico del glutammato mGlu5 in un modello di schizofrenia indotta da trattamen...
Studio del meccanismo d'azione di farmaci modulatori allosterici positivi (PAM) del recettore metabotropico del glutammato mGlu5 e della loro attività come "biased agonists": implicazioni nel trattamento della schizofrenia.
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