Sergio Valente

Pubblicazioni

Titolo Pubblicato in Anno
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni ACS INFECTIOUS DISEASES 2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 JOURNAL OF MEDICINAL CHEMISTRY 2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages CHEMMEDCHEM 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response FRONTIERS IN ENDOCRINOLOGY 2022
Histone-deacetylase 8 drives the immune response and the growth of glioma GLIA 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction JOURNAL OF MEDICINAL CHEMISTRY 2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders JOURNAL OF MEDICINAL CHEMISTRY 2021
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology FRONTIERS IN PHARMACOLOGY 2021
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression GASTROENTEROLOGY 2021
Editorial: Natural Product Epigenetic Modulators and Inhibitors FRONTIERS IN PHARMACOLOGY 2021
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis FRONTIERS IN PHARMACOLOGY 2020
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation CHEMMEDCHEM 2020
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation SCIENCE ADVANCES 2020
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action REDOX BIOLOGY 2020
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene HUMAN GENETICS 2020
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization ACS CHEMICAL BIOLOGY 2020
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells ACS MEDICINAL CHEMISTRY LETTERS 2020

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