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sergio.valente@uniroma1.it
Sergio Valente
Professore Associato
Struttura:
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
E-mail:
sergio.valente@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
JOURNAL OF MEDICINAL CHEMISTRY
2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
GREEN CHEMISTRY
2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
CELLS
2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
JOURNAL OF MEDICINAL CHEMISTRY
2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors
CURRENT OPINION IN STRUCTURAL BIOLOGY
2023
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS
ANTIOXIDANTS
2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE
2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules
THERANOSTICS
2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
ACS INFECTIOUS DISEASES
2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
JOURNAL OF MEDICINAL CHEMISTRY
2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages
CHEMMEDCHEM
2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
CELL DEATH & DISEASE
2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2022
Histone-deacetylase 8 drives the immune response and the growth of glioma
GLIA
2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction
JOURNAL OF MEDICINAL CHEMISTRY
2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders
JOURNAL OF MEDICINAL CHEMISTRY
2021
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology
FRONTIERS IN PHARMACOLOGY
2021
Editorial: Natural Product Epigenetic Modulators and Inhibitors
FRONTIERS IN PHARMACOLOGY
2021
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Progetti di Ricerca
Design and biological evaluation of novel epigenetic dual-targeting modulators to fight cancer
Laboratori di ricerca
LABORATORIO 256
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