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sergio.valente@uniroma1.it
Sergio Valente
Professore Associato
Struttura:
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
E-mail:
sergio.valente@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE
2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules
THERANOSTICS
2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
ACS INFECTIOUS DISEASES
2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
JOURNAL OF MEDICINAL CHEMISTRY
2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages
CHEMMEDCHEM
2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
CELL DEATH & DISEASE
2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2022
Histone-deacetylase 8 drives the immune response and the growth of glioma
GLIA
2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction
JOURNAL OF MEDICINAL CHEMISTRY
2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders
JOURNAL OF MEDICINAL CHEMISTRY
2021
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology
FRONTIERS IN PHARMACOLOGY
2021
Editorial: Natural Product Epigenetic Modulators and Inhibitors
FRONTIERS IN PHARMACOLOGY
2021
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis
FRONTIERS IN PHARMACOLOGY
2020
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation
CANCERS
2020
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation
CHEMMEDCHEM
2020
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
SCIENCE ADVANCES
2020
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action
REDOX BIOLOGY
2020
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene
HUMAN GENETICS
2020
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Progetti di Ricerca
Design and biological evaluation of novel epigenetic dual-targeting modulators to fight cancer
Laboratori di ricerca
LABORATORIO 256
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