Sergio Valente

Pubblicazioni

Titolo Pubblicato in Anno
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey JOURNAL OF MEDICINAL CHEMISTRY 2023
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design GREEN CHEMISTRY 2023
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery CELLS 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS ANTIOXIDANTS 2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules THERANOSTICS 2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni ACS INFECTIOUS DISEASES 2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 JOURNAL OF MEDICINAL CHEMISTRY 2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages CHEMMEDCHEM 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Histone-deacetylase 8 drives the immune response and the growth of glioma GLIA 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction JOURNAL OF MEDICINAL CHEMISTRY 2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders JOURNAL OF MEDICINAL CHEMISTRY 2021
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology FRONTIERS IN PHARMACOLOGY 2021
Editorial: Natural Product Epigenetic Modulators and Inhibitors FRONTIERS IN PHARMACOLOGY 2021

Progetti di Ricerca

Laboratori di ricerca

LABORATORIO 256

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