Serena Rinaldo


Titolo Pubblicato in Anno
A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins COORDINATION CHEMISTRY REVIEWS 2022
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex THE FEBS JOURNAL 2022
Nutrient sensing and biofilm modulation: the example of L-arginine in Pseudomonas INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex 2022
Inhibition of Glycolysis Impairs Retinoic Acid-Inducible Gene I-Mediated Antiviral Responses in Primary Human Dendritic Cells FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2022
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms SCIENCE ADVANCES 2022
Studying ggdef domain in the act: Minimize conformational frustration to prevent artefacts LIFE 2021
High-fat diet leads to reduced protein o-glcnacylation and mitochondrial defects promoting the development of alzheimer’s disease signatures INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021
Importance of amino acids in brain parenchyma invasion by cancer cells ONCOSCIENCE 2021
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 16th SIBBM Seminar Frontiers in Molecular Biology Frontiers in metabolic research Abstracts 2021
Signal transduction and c-di-GMP second messenger: novel tools to investigare the mechanism of nutrient sensing. WEBPRO - Proteins on the Web 2021. 2021
L- Arginine in Pseudomonas aeruginosa controls c-di-GMP levels and biofilm formation efb 2021 2021
Structural clues of Serine hidroxymethyltransferase (SHMT) riboregulation 2nd Italian Crystallographic Association Biological MacroMolecules Group Meeting 2021
The emerging role of amino acids of the brain microenvironment in the process of metastasis formation CANCERS 2021
Determining folding and binding properties of the C-terminal SH2 domain of SHP2 PROTEIN SCIENCE 2021
Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY 2021
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity CELL DEATH & DISEASE 2020
Structure and function of HD-GYP phosphodiesterases Microbial Cyclic Di-Nucleotide Signaling 2020
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism NUCLEIC ACIDS RESEARCH 2019


  • LS1_1
  • LS1_2
  • LS1_7
  • LS1_9


  • Life-science technologies & biotechnologies

Interessi di ricerca

The scientific activity of Serena Rinaldo is focused on the molecular aspects of proteins involved in biological processes crucial for cell maintenance and communication to dissect the mechanism of pathological conditions (including chronic infections and cancer), using a multidisciplinary approach encompassing Molecular Biology, Biochemistry and Structural Biology.

A schematic summary of the main research lines is reported below:

- Small molecules (nucleotides) involved in the formation of bacterial biofilm in chronic infections; integration of protein engineering and molecular biophysics approaches allowed the identification of structural determinants controlling the interaction of selected enzymes with small molecules (such as c-di-GMP, nucleotides and metals) and inhibitors, identified thanks to fruitful collaborations with medicinal chemists (Prof. Cappellacci l., Camerino, I). More recently, the role of strategic nutrients in controlling c-di-GMP levels has been investigated by mechanistic approach.

- Role of nitric oxide and redox metabolism in bacterial pathogens; the specific expertise acquired during the PhD and the first Post-Doc period of Serena Rinaldo allowed to re-evaluate the role of oxygen and the interaction of nitric oxide with metalloproteins and, broadly speaking, with the heme cofactor, as acknowledged by the publication records.

- Metabolic reprogramming in cancer cells and ageing, by looking at the role of enzymes of the serine/glycine pathway and one-carbon metabolism; she contributed to define the role of SHMT protein dynamic upon cofactor and substrates binding, relevant to rationally design compounds able to inhibit protein function. She developed a binding assay for testing enzyme inhibitors.

The main expertise is:

recombinant proteins production and characterization, protein/nucleic acid interaction, nucleotide and redox biochemistry, enzyme kinetics, microcalorimetry ITC, respiratory measurements (Seahorse).


protein engineering
cyclic nucleotide phosphodiesterase
energy metabolism

Gruppi di ricerca

Gruppi di ricerca - Responsabile

Laboratori di ricerca

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