Antonio Francesco Campese

Pubblicazioni

Titolo Pubblicato in Anno
Evaluation of the Therapeutic Effects of Harmine on Anaplastic Thyroid Cancer Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia FRONTIERS IN IMMUNOLOGY 2022
CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells CANCER BIOLOGY & MEDICINE 2021
Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects THE FASEB JOURNAL 2020
NF-κB1 Regulates Immune Environment and Outcome of Notch-Dependent T-Cell Acute Lymphoblastic Leukemia FRONTIERS IN IMMUNOLOGY 2020
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 NATURE COMMUNICATIONS 2018
NOTCH1 is aberrantly activated in chronic lymphocytic leukemia hematopoietic stem cells FRONTIERS IN ONCOLOGY 2018
Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation. ONCOGENE 2018
Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells ONCOTARGET 2018
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer FRONTIERS IN IMMUNOLOGY 2018
Notch3 and CXCR4 cross-signaling sustains acute T-cell leukemia progression ESMO OPEN 2018
The mazy case of Notch and immunoregulatory cells JOURNAL OF LEUKOCYTE BIOLOGY 2017
Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations HUMAN MOLECULAR GENETICS 2016
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression ONCOGENE 2016
Notch3 sustains CXCR4 expression in acute T cell lymphoblastic leukemia progression EUROPEAN JOURNAL OF CANCER 2016
Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells INTERNATIONAL JOURNAL OF CANCER 2015
Consequences of simulated microgravity in neural stem cells: biological effects and metabolic response. JOURNAL OF STEM CELL RESEARCH AND THERAPY 2015
Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy HUMAN MOLECULAR GENETICS 2015
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β ONCOTARGET 2015

ERC

  • LS3_9
  • LS4_11
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I principali interessi dell'attività di ricerca, mediante utilizzo di tecniche di immunologia e biologia molecolare per la caratterizzazione di modelli murini, si sono sviluppati lungo le direttive di seguito descritte:

1) Notch nel differenziamento dei linfociti T e nello sviluppo della 'Leucemia linfoblastica acuta a cellule T' (T-ALL).

2) Il ruolo di Notch ed NF-kB nel controllo della generazione e della funzione delle cellule T regolatorie e nella patogenesi del diabete autoimmune sperimentale.

3) Notch ed NF-kB nell'interazione tra le cellule T leucemiche e le cellule immunosoppressorie (Treg ed MDSC) nel microambiente tumorale.

 

Keywords

Notch
T-ALL
MDSC
Treg

Laboratori di ricerca

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