Stefano Gianni | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chains	JOURNAL OF MOLECULAR BIOLOGY	2025
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS	2024
Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods.	GENOME BIOLOGY	2024
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2024
The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State	JOURNAL OF MOLECULAR BIOLOGY	2024
Folding and binding kinetics of the tandem of SH2 domains from SHP2	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2024
A PDZ tandem repeat folds and unfolds via different pathways	PROTEIN SCIENCE	2024
Allostery Frustrates the Experimentalist	JOURNAL OF MOLECULAR BIOLOGY	2023
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2023
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators	BIOORGANIC CHEMISTRY	2023
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
An intramolecular energetic network regulates ligand recognition in a SH2 domain	PROTEIN SCIENCE	2023
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS	2023
Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor	CANCERS	2022
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains	BIOMOLECULES	2022
Characterization of early and late transition states of the folding pathway of a SH2 domain	PROTEIN SCIENCE	2022
Folding and binding mechanisms of the SH2 domain from Crkl	BIOMOLECULES	2022
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat	PROTEIN SCIENCE	2022
Exploring the effect of tethered domains on the folding of Grb2 protein	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS	2022

Progetti di Ricerca

Laboratori di ricerca

Cinetica Rapida - ANALYSIS OF RAPID PROCESSES (ARP)