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Pubblicazioni

Titolo Pubblicato in Anno
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
Modeling myotonic dystrophy type 2 using Drosophila melanogaster INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma CELL DEATH AND DIFFERENTIATION 2023
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question CANCERS 2022
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor JOURNAL OF MEDICINAL CHEMISTRY 2022
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function ELIFE 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer FRONTIERS IN ONCOLOGY 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation INTERNATIONAL JOURNAL OF ONCOLOGY 2019
Polyamine metabolism as a therapeutic target in hedgehog-driven basal cell carcinoma and medulloblastoma CELLS 2019
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis NATURE COMMUNICATIONS 2018
Targeting metabolic vulnerabilities to treat Shh medulloblastoma INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2018
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma ONCOGENE 2017
Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance INTERNATIONAL JOURNAL OF CANCER 2017
Targeting Gli acetylation in Shh-medulloblastoma: A successful preclinical approach INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma SCIENTIFIC REPORTS 2017
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint ONCOTARGET 2016

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EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)

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