Laura Di Magno

Pubblicazioni

Titolo Pubblicato in Anno
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation ONCOGENE 2024
Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery NATURE COMMUNICATIONS 2024
Development of N-(4-(1 H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability JOURNAL OF MEDICINAL CHEMISTRY 2024
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability CANCERS 2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE 2023
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential JOURNAL OF HEPATOLOGY 2022
Opposite effect of thyroid hormones on oxidative stress and on mitochondrial respiration in COVID-19 patients ANTIOXIDANTS 2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question CANCERS 2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5 CELLS 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response ONCOGENESIS 2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc CHEMMEDCHEM 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation INTERNATIONAL JOURNAL OF ONCOLOGY 2019
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents ACS MEDICINAL CHEMISTRY LETTERS 2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP NATURE COMMUNICATIONS 2019
Polyamine metabolism as a therapeutic target in hedgehog-driven basal cell carcinoma and medulloblastoma CELLS 2019

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Metabolic reprogramming, energy sensors, NADH homeostasis, metabolic targeting, drug design and validation.

Keywords

cancer metabolism
bioenergetics
redox imbalance

Progetti di Ricerca

Gruppi di ricerca

EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma