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laura.dimagno@uniroma1.it
Laura Di Magno
Ricercatore
Struttura:
DIPARTIMENTO DI MEDICINA MOLECOLARE
E-mail:
laura.dimagno@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
ONCOGENE
2024
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability
CANCERS
2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation
CANCER LETTERS
2023
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
2023
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
JOURNAL OF MEDICINAL CHEMISTRY
2023
Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential
JOURNAL OF HEPATOLOGY
2022
Opposite effect of thyroid hormones on oxidative stress and on mitochondrial respiration in COVID-19 patients
ANTIOXIDANTS
2022
The Mechanism of Action of Biguanides: New Answers to a Complex Question
CANCERS
2022
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2022
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5
CELLS
2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module
CELL REPORTS
2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
ONCOGENESIS
2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc
CHEMMEDCHEM
2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation
CELL DEATH & DISEASE
2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation
INTERNATIONAL JOURNAL OF ONCOLOGY
2019
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
ACS MEDICINAL CHEMISTRY LETTERS
2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
NATURE COMMUNICATIONS
2019
Polyamine metabolism as a therapeutic target in hedgehog-driven basal cell carcinoma and medulloblastoma
CELLS
2019
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2
ONCOGENESIS
2019
Targeting metabolic vulnerabilities to treat Shh medulloblastoma
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2018
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Progetti di Ricerca
Studio del ruolo dell'asse CNBP-MYC nel cancro del colon-retto
Gruppi di ricerca
EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)
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