Gianluca Canettieri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2021
Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5	CELLS	2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors	ONCOGENE	2021
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function	ELIFE	2021
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids	CELL DEATH & DISEASE	2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module	CELL REPORTS	2020
Aged garlic extract and its constituent, S-allyl-L-cysteine, induce the apoptosis of neuroblastoma cancer cells due to mitochondrial membrane depolarization	EXPERIMENTAL AND THERAPEUTIC MEDICINE	2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i	CANCERS	2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer	FRONTIERS IN ONCOLOGY	2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response	ONCOGENESIS	2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth	MOLECULAR ONCOLOGY	2020
Nanotechnology-based strategies to develop new anticancer therapies	BIOMOLECULES	2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc	CHEMMEDCHEM	2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation	CELL DEATH & DISEASE	2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation	INTERNATIONAL JOURNAL OF ONCOLOGY	2019
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents	ACS MEDICINAL CHEMISTRY LETTERS	2019
A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer	CANCERS	2019
Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells	INTERNATIONAL JOURNAL OF ONCOLOGY	2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Polyamine metabolism as a therapeutic target in hedgehog-driven basal cell carcinoma and medulloblastoma	CELLS	2019

ERC

LS4_9
LS4_12

KET

Life-science technologies & biotechnologies

Keywords

Colorectal cancer

Medulloblastoma

cancer metabolism

Hedgehog (Hh) pathway

epigenetic

redox imbalance

biguanides

polyamine metabolism

translation

gene transcription

AMPK

C-Myc

Progetti di Ricerca

Gruppi di ricerca - Responsabile

EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)