Gianluca Canettieri

Pubblicazioni

Titolo Pubblicato in Anno
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis NATURE COMMUNICATIONS 2018
The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability INTERNATIONAL JOURNAL OF ONCOLOGY 2018
Targeting metabolic vulnerabilities to treat Shh medulloblastoma INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2018
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma ONCOGENE 2017
Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance INTERNATIONAL JOURNAL OF CANCER 2017
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells BMC CANCER 2017
Targeting Gli acetylation in Shh-medulloblastoma: A successful preclinical approach INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma SCIENTIFIC REPORTS 2017
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint ONCOTARGET 2016
Translating Hedgehog in Cancer: Controlling Protein Synthesis TRENDS IN MOLECULAR MEDICINE 2016
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype CELL DEATH & DISEASE 2016
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors EMBO JOURNAL 2015
Digging a hole under Hedgehog: Downstream inhibition as an emerging anticancer strategy BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 2015
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth DEVELOPMENTAL CELL 2015
Determination of acetylation of the Gli transcription factors Hedgehog signaling protocols 2015

ERC

  • LS4_9
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Keywords

Colorectal cancer
Medulloblastoma
cancer metabolism
Hedgehog (Hh) pathway
epigenetic
redox imbalance
biguanides
polyamine metabolism
translation
gene transcription
AMPK
C-Myc

Progetti di Ricerca

Gruppi di ricerca - Responsabile

EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)

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