Ricerc@Sapienza

- regulation of DNA methylation and demethylation processes in eukaryotic cells;

- DNA methylation, modulation of gene expression and cell differentiation;

- molecular mechanisms of the gene therapy by small fragment homologous replacement (SFHR);

- molecular genetics of cystic fibrosis and of CFTR-related disorders and study of the genotype/phenotype relationship in this diseases;

- theratyping of cystic fibrosis;

- functional characterization of CFTR (cystic fibrosis transmembrane conductance regulator) and ENaC (epithelial sodium channel) genes in physiologic and pathologic conditions;

- molecular diagnostic methodologies and pathogenetic mechanisms underlying cystic fibrosis, CFTR-related disorders, atherosclerosis, alcohol addiction and neurological disorders;

- setup and automation of mutational search methodologies.