Fabio Di Domenico | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Redox imbalance and metabolic defects in the context of Alzheimer disease	FEBS LETTERS	2024
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease	PHYSIOLOGICAL REVIEWS	2024
Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model	NEUROBIOLOGY OF DISEASE	2024
Biliverdin reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β	REDOX BIOLOGY	2024
Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimer’s disease-like neuropathology in a mouse model for Down syndrome	ANTIOXIDANTS	2023
Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome	NEUROPHARMACOLOGY	2023
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome	FREE RADICAL BIOLOGY & MEDICINE	2022
The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders	ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY	2022
Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome	FREE RADICAL BIOLOGY & MEDICINE	2021
Stress responses in down syndrome neurodegeneration: State of the art and therapeutic molecules	BIOMOLECULES	2021
High-fat diet leads to reduced protein o-glcnacylation and mitochondrial defects promoting the development of alzheimer’s disease signatures	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles	ALZHEIMER'S & DEMENTIA	2021
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease	FREE RADICAL BIOLOGY & MEDICINE	2021
mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder	FREE RADICAL BIOLOGY & MEDICINE	2021
Broad kinase inhibition mitigates early neuronal dysfunction in tauopathy	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimer’s dysmetabolism, neuropathology, and possible therapies	FREE RADICAL BIOLOGY & MEDICINE	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)	AUTOPHAGY	2021
Protein oxidative damage in UV-related skin cancer and dysplastic lesions contributes to neoplastic promotion and progression	CANCERS	2020
Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome	NEUROBIOLOGY OF DISEASE	2020
The anti-diabetic drug metformin rescues aberrant mitochondrial activity and restrains oxidative stress in a female mouse model of rett syndrome	JOURNAL OF CLINICAL MEDICINE	2020

Progetti di Ricerca

Deciphering the the interplay between the unfolded protein response and insulin resistance in Down syndrome brain
Inhibition of PERK pathway for the early treatment of Alzheimer Disease-like cognitive decline in Down Syndrome
The sweet link between aberrant brain metabolism and cognitive decline: A novel role for altered protein O-GlcNAcylation.
Deciphering the role of aberrant PERK/NRF2 axis in Down Syndrome