Alessandro Paiardini

Pubblicazioni

Titolo Pubblicato in Anno
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase PROTEIN SCIENCE 2024
Making Use of Averaging Methods in MODELLER for Protein Structure Prediction INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024
Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions FRONTIERS IN IMMUNOLOGY 2024
AlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach NUCLEIC ACIDS RESEARCH 2024
STRUCTURE-BASED MECHANISM OF RIBOREGULATION OF THE METABOLIC ENZYME SHMT1 MOLECULAR CELL 2024
The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target THE FEBS JOURNAL 2024
An inherited TBX3 alteration in a prenatal case of ulnar‐mammary syndrome: Clinical assessment and functional characterization in Drosophila melanogaster JOURNAL OF CELLULAR PHYSIOLOGY 2024
An outlook on structural biology after AlphaFold: tools, limits and perspectives FEBS OPEN BIO 2024
A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression CANCER GENE THERAPY 2023
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation LIFE SCIENCE ALLIANCE 2023
Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1 LIFE SCIENCE ALLIANCE 2023
Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds SCIENTIFIC REPORTS 2023
Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF MICROBIOLOGY SPECTRUM 2023
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells FRONTIERS IN IMMUNOLOGY 2023
First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8 JOURNAL OF MEDICINAL CHEMISTRY 2023
When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri SCIENTIFIC REPORTS 2023
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa. MICROBIOLOGICAL RESEARCH 2023
Exploring Innovative Approaches to Isolate a One-Component c-di-GMP Transducer: A Pilot Study ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2023
A deep neural network for G-quadruplexes binding proteins classification Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2023

ERC

  • LS1
  • LS1_8
  • LS1_12
  • LS1_14
  • LS2_11

KET

  • Big data & computing
  • Life-science technologies & biotechnologies

Interessi di ricerca

Bioinformatics, Computational Biology, Medicinal Chemistry, Drug Design, Protein Structure Prediction, Deep Learning, GUI programming, Python, Cancer, Kinases

Progetti di Ricerca

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma