Pubblicazioni

ALS-associated FUS mutation reshapes the RNA and protein composition of stress granules

2024 - NUCLEIC ACIDS RESEARCH

Mariani, Davide; Setti, Adriano; Castagnetti, Francesco; Vitiello, Erika; Stufera Mecarelli, Lorenzo; Di Timoteo, Gaia; Giuliani, Andrea; D'Angelo, Angelo; Santini, Tiziana; Perego, Eleonora; Zappone, Sabrina; Liessi, Nara; Armirotti, Andrea; Vicidomini, Giuseppe; Bozzoni, Irene

Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons

2023 - CELL DEATH DISCOVERY

Garone, Maria Giovanna; Salerno, Debora; Rosa, Alessandro

FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation

2023 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Colantoni, Alessio; Capauto, Davide; Alfano, Vincenzo; D'Ambra, Eleonora; D'Uva, Sara; Tartaglia, GIAN GAETANO; Morlando, Mariangela

Upregulation of Î²-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis

2022 - STEM CELL REPORTS

Hawkins, S.; Namboori, S. C.; Tariq, A.; Blaker, C.; Flaxman, C.; Dey, N. S.; Henley, P.; Randall, A.; Rosa, A.; Stanton, L. W.; Bhinge, A.

La Corte dichiara il finanziamento âextra-FUSâ al teatro Eliseo âincongruoâ, âsproporzionatoâ e idoneo ad alterare la libera concorrenza

2022 - NOMOS. LE ATTUALITÃ NEL DIRITTO

Tripodi, Ludovica

ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity

2021 - COMMUNICATIONS BIOLOGY

Garone, M. G.; Birsa, N.; Rosito, M.; Salaris, F.; Mochi, M.; de Turris, V.; Nair, R. R.; Cunningham, T. J.; Fisher, E. M. C.; Morlando, M.; Fratta, P.; Rosa, A.

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

2021 - STEM CELL REPORTS

Stoklund Dittlau, K.; Krasnow, E. N.; Fumagalli, L.; Vandoorne, T.; Baatsen, P.; Kerstens, A.; Giacomazzi, G.; Pavie, B.; Rossaert, E.; Beckers, J.; Sampaolesi, M.; Van Damme, P.; Van Den Bosch, L.

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

2020 - NUCLEIC ACIDS RESEARCH

Humphrey, Jack; Birsa, Nicol; Milioto, Carmelo; McLaughlin, Martha; Ule, Agnieszka M; Robaldo, David; Eberle, Andrea B; KrÃ¤uchi, Rahel; Bentham, Matthew; Brown, Anna-Leigh; Jarvis, Seth; Bodo, Cristian; Garone, Maria G; Devoy, Anny; Soraru, Gianni; Rosa, Alessandro; Bozzoni, Irene; Fisher, Elizabeth M C; MÃ¼hlemann, Oliver; Schiavo, Giampietro; Ruepp, Marc-David; Isaacs, Adrian M; Plagnol, Vincent; Fratta, Pietro

Promiscuous roles of autophagy and proteasome in neurodegenerative proteinopathies

2020 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Limanaqi, F.; Biagioni, F.; Gambardella, S.; Familiari, P.; Frati, A.; Fornai, F.

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3â²UTR binding

2020 - SCIENTIFIC REPORTS

Garone, Maria Giovanna; Alfano, Vincenzo; Salvatori, Beatrice; Braccia, Clarissa; Peruzzi, Giovanna; Colantoni, Alessio; Bozzoni, Irene; Armirotti, Andrea; Rosa, Alessandro

Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in Amyotrophic Lateral Sclerosis

2019 - CELL REPORTS

De Santis, R.; Alfano, V.; de Turris, V.; Colantoni, A.; Santini, L.; Garone, M. G.; Antonacci, G.; Peruzzi, G.; Sudria-Lopez, E.; Wyler, E.; Anink, J. J.; Aronica, E.; Landthaler, M.; Pasterkamp, R. J.; Bozzoni, I.; Rosa, A.

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons

2018 - MOLECULAR NEUROBIOLOGY

Capauto, Davide; Colantoni, Alessio; Lu, Lei; Santini, Tiziana; Peruzzi, Giovanna; Biscarini, Silvia; Morlando, Mariangela; Shneider, Neil A.; Caffarelli, Elisa; Laneve, Pietro; Bozzoni, Irene

Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS

2018 - STEM CELL RESEARCH

Biscarini, Silvia; Capauto, Davide; Peruzzi, Giovanna; Lu, Lei; Colantoni, Alessio; Santini, Tiziana; Shneider, Neil A; Caffarelli, Elisa; Laneve, Pietro; Bozzoni, Irene

Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS

2018 - COMMUNICATIONS BIOLOGY

Antonacci, Giuseppe; DE TURRIS, Valeria; Rosa, Alessandro; Ruocco, Giancarlo

Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice (vol 7, 2033, 2017)

2018 - SCIENTIFIC REPORTS

Mirra, A; Rossi, S; Scaricamazza, S; Di Salvio, M; Salvatori, I; Valle, C; Rusmini, P; Poletti, A; Cestra, G; Carri, Mt; Cozzolino, M

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

2016 - ACTA NEUROPATHOLOGICA

Blokhuis, Anna M.; Koppers, Max; Groen, Ewout J. N.; van Den Heuvel, Dianne M. A.; DINI MODIGLIANI, Stefano; Anink, Jasper J.; Fumoto, Katsumi; van Diggelen, Femke; Snelting, Anne; Sodaar, Peter; Verheijen, Bert M.; Demmers, Jeroen A. A.; Veldink, Jan H.; Aronica, Eleonora; Bozzoni, Irene; Den Hertog, Jeroen; van Den Berg, Leonard H.; Pasterkamp, R. Jeroen

ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cells- derived motoneurons

2015 - DISEASE MODELS & MECHANISMS

Lenzi, Jessica; DE SANTIS, Riccardo; Turris, Valeria de; Morlando, Mariangela; Laneve, Pietro; Calvo, Andrea; Caliendo, Virginia; ChiÃ², Adriano; Rosa, Alessandro; Bozzoni, Irene