Pubblicazioni

Metformin is a pyridoxal-5â²-phosphate (PLP)-competitive inhibitor of SHMT2

2021 - CANCERS

Tramonti, A.; Cuyas, E.; Encinar, J. A.; Pietzke, M.; Paone, A.; Verdura, S.; Arbusa, A.; Martin-castillo, B.; Giardina, G.; Joven, J.; Vazquez, A.; Contestabile, R.; Cutruzzola', F; Menendez, J. A.

Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium aphanothece halophytica provide a rationale for salt tolerance

2020 - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

NoguÃ©s, Isabel; Tramonti, Angela; Angelaccio, Sebastiana; Ruszkowski, Milosz; Sekula, Bartosz; Contestabile, Roberto

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes

2018 - ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tramonti, Angela; Paiardini, Alessandro; Paone, Alessio; Bouzidi, Amani; Giardina, Giorgio; Guiducci, Giulia; Magnifico, Maria Chiara; Rinaldo, Serena; Mcdermott, Lee; Menendez, Javier A.; Contestabile, Roberto; CutruzzolÃ , Francesca

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells

2016 - ONCOTARGET

Marani, Marina; Paone, Alessio; Fiascarelli, Alessio; Macone, Alberto; Gargano, Maurizio; Rinaldo, Serena; Giardina, Giorgio; Pontecorvi, Valentino; Koes, David; Mcdermott, Lee; Yang, Tianyi; Paiardini, Alessandro; Contestabile, Roberto; Cutruzzola', Francesca

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming

2016 - BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Paiardini, Alessandro; Tramonti, Angela; Schirch, Doug; Guiducci, Giulia; Di Salvo, Martino Luigi; Fiascarelli, Alessio; Giorgi, Alessandra; Maras, Bruno; Cutruzzola', Francesca; Contestabile, Roberto

Conserved water molecules in bacterial serine hydroxymethyltransferases

2015 - PROTEIN ENGINEERING, DESIGN & SELECTION

Milano, Teresa; DI SALVO, Martino Luigi; Angelaccio, Sebastiana; Pascarella, Stefano